Genetic variants of major genes contributing to phosphate and calcium homeostasis and their association with serum parameters in pigs.
Genetic variants of major genes contributing to phosphate and calcium homeostasis and their association with serum parameters in pigs.
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DOI：
10.1007/s13353-018-0449-2
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发表时间：
2018-08
影响因子：
2.4
通讯作者：
Wimmers K
中科院分区：
文献类型：
--
作者：
Just F;Reyer H;Muráni E;Ponsuksili S;Oster M;Wimmers K
钙和磷是生命不可替代的组成部分。由于钙和磷与骨代谢以及随后的动物健康的相关性，追踪生物体中钙和磷的命运值得高度关注。事实上，骨骼是钙和磷的储存库，其形成和吸收遵循特定的分子途径，包括激素、受体和转录因子。该研究的目的是分析驱动矿物质利用的主要成分的遗传变异，例如降钙素受体、钙敏感受体、成纤维细胞生长因子23 (FGF23)、甲状旁腺激素受体、骨桥蛋白、斯钙素1、RAF型锌指结构域1 (TRAFD1)和维生素D受体。采用德国长白猪群体（n = 360）对选定的单核苷酸多态性（SNP）与相关血清参数（钙、磷、钙/磷比、碱性磷酸酶）之间进行关联分析。分析的 FGF23 (rs710498025) 和 TRAFD1 (rs345195312) 中的 SNP 分别与血清钙/磷比和血清磷水平显着相关 (p≤≤0.05)。这可能代表了钙和磷之间稳态平衡的调节。此外，已知 TRAFD1 与骨骼疾病有关，这强调了它与磷利用和免疫系统的联系。然而，在经过多次测试校正后，这些磷酸盐和钙稳态主要调节因子的分析遗传变异均未显示出显着关联（q值> 0.05）。因此，需要对矿物质稳态的次要贡献者以及未知且尚未阐明的调节因子进行表征，以在养猪计划中实施提高磷效率的实施。本文的在线版本 (10.1007/s13353-018-0449-2) 包含补充材料，可供授权用户使用。
Calcium and phosphorus are irreplaceable components of life. Tracking the fate of calcium and phosphorus in organisms deserves high attention due to their relevance in bone metabolism and subsequently animal health. Indeed, bone serves as reservoir for calcium and phosphorus, whose formation and resorption follow specific molecular routes including hormones, receptors, and transcription factors. The objective of the study was to analyze the genetic variation of major components driving mineral utilization such as calcitonin receptor, calcium sensing receptor, fibroblast growth factor 23 (FGF23), parathyroid hormone receptor, osteopontin, stanniocalcin 1, RAF-type zinc finger domain containing 1 (TRAFD1), and vitamin D receptor. A German Landrace pig population (n = 360) was used to perform an association analysis between selected single nucleotide polymorphisms (SNP) and relevant serum parameters (calcium, phosphorus, calcium/phosphorus ratio, alkaline phosphatase). Analyzed SNPs in FGF23 (rs710498025) and TRAFD1 (rs345195312) were significantly (p ≤ 0.05) associated with the serum calcium/phosphorus ratio and serum phosphorus levels, respectively. This might represent a modulation of the homeostatic balance between calcium and phosphorus. Furthermore, TRAFD1 is known to be involved in skeletal disorders which emphasize its link to phosphorus utilization and immune system. However, none of the analyzed genetic variants of these major regulators of phosphate and calcium homeostasis showed significant associations after correction for multiple testing (q value > 0.05). Thus, minor contributors as well as unknown and yet to be elucidated regulators of mineral homeostasis need to be characterized towards the implementation of improved phosphorus efficiency in pig breeding programs. The online version of this article (10.1007/s13353-018-0449-2) contains supplementary material, which is available to authorized users.
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