A Mechanistic DNA Repair and Survival Model (Medras): Applications to Intrinsic Radiosensitivity, Relative Biological Effectiveness and Dose-Rate.
A Mechanistic DNA Repair and Survival Model (Medras): Applications to Intrinsic Radiosensitivity, Relative Biological Effectiveness and Dose-Rate.
复制标题
DOI：
10.3389/fonc.2021.689112
复制
发表时间：
2021
影响因子：
4.7
通讯作者：
Prise KM
中科院分区：
文献类型：
--
作者：
McMahon SJ;Prise KM
现在普遍认为，不同细胞对电离辐射的内在放射敏感性的差异是导致放射治疗反应差异的重要驱动因素。虽然辐射敏感性的机制已经在实验室中得到了广泛的研究，但缺乏将这些知识整合到预测框架中的模型。本文介绍了Medras模型的概述，该模型已被开发来提供一个机制框架，在该框架中可以对不同的辐射响应进行建模和预测个体响应。该模型模拟了辐射诱导的DNA损伤的修复，结合了修复的整体动力学及其保真度，以预测一系列生物终点，包括残留DNA损伤、突变、染色体畸变和细胞死亡。该模型针对一系列暴露类型进行了验证，包括考虑了不同的辐射质量和剂量率。这种方法有可能为新的工具提供信息，以提供辐射敏感性的机械性预测，并支持未来个性化治疗的发展。
Variations in the intrinsic radiosensitivity of different cells to ionizing radiation is now widely believed to be a significant driver in differences in response to radiotherapy. While the mechanisms of radiosensitivity have been extensively studied in the laboratory, there are a lack of models which integrate this knowledge into a predictive framework. This paper presents an overview of the Medras model, which has been developed to provide a mechanistic framework in which different radiation responses can be modelled and individual responses predicted. This model simulates the repair of radiation-induced DNA damage, incorporating the overall kinetics of repair and its fidelity, to predict a range of biological endpoints including residual DNA damage, mutation, chromosome aberration, and cell death. Validation of this model against a range of exposure types is presented, including considerations of varying radiation qualities and dose-rates. This approach has the potential to inform new tools to deliver mechanistic predictions of radiation sensitivity, and support future developments in treatment personalization.
登录
查看更多内容
影响因子：
2.9
作者：
Ballarini, Francesca;Carante, Mario P.
通讯作者：
Carante, Mario P.
DOI：
10.1016/0360-3016(81)90377-1
发表时间：
1981-01-01
影响因子：
7
作者：
FERTIL, B;MALAISE, EP
通讯作者：
MALAISE, EP
影响因子：
2.6
作者：
DEALMODOVAR, JMR;STEEL, GG;MCMILLAN, TJ
通讯作者：
MCMILLAN, TJ
DOI：
10.3109/02841868609136393
发表时间：
1986-03-01
期刊：
ACTA RADIOLOGICA ONCOLOGY
影响因子：
--
作者：
FABRY, L
通讯作者：
FABRY, L
影响因子：
11.2
作者：
Amundson, Sally A.;Do, Khanh T.;Fornace, Albert J., Jr.
通讯作者：
Fornace, Albert J., Jr.