Suppression of male courtship by a Drosophila pheromone receptor.

Suppression of male courtship by a Drosophila pheromone receptor.
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DOI:
10.1038/nn.2161
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发表时间:
2008-08
影响因子:
25
通讯作者:
Amrein H
Amrein H
中科院分区:
医学1区
文献类型:
--
作者:
Miyamoto T;Amrein H

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在雄性果蝇中,化学感觉线索控制着社会行为的许多方面。我们发现,突变的味觉受体32a基因(GR32a)的男性表现出较高的求爱对男性和交配的女性,表明GR32a的功能作为一个信息素受体的男性抑制性信息素。值得注意的是,我们发现,跗骨Gr32a表达神经元是必不可少的求偶抑制和投射到腹外侧前脑,这意味着直接沟通的化学感觉神经元与高阶大脑结构。
In male Drosophila, chemosensory cues control many aspects of social behavior. We found that males with a mutated Gustatory receptor 32a gene (Gr32a) show high courtship toward males and mated females, indicating that GR32a functions as a pheromone receptor for a male inhibitory pheromone. Notably, we discovered that tarsal Gr32a-expressing neurons were essential for courtship suppression and projected to the ventrolateral protocerebrum, implying direct communication of chemosensory neurons with a higher-order brain structure.
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