bFGF could be a biomarker of malignancy in RS(3)PE syndrome: an ambispective single-center cohort analysis of 51 patients.
bFGF could be a biomarker of malignancy in RS(3)PE syndrome: an ambispective single-center cohort analysis of 51 patients.
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bFGF 可能是 RS3PE 综合征恶性肿瘤的生物标志物：对 51 名患者进行的双向单中心队列分析
DOI：
10.1186/s13075-021-02638-0
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发表时间：
2021-10-15
影响因子：
4.9
通讯作者：
Ye H
中科院分区：
文献类型：
--
作者：
Gan Y;Sun Y;Jin J;Wang Y;Chen J;Chung Y;Li X;Ye H
缓解性血清阴性对称性滑膜炎伴凹陷性水肿(RS3PE)是一种罕见的炎症性关节炎，恶性肿瘤发生率较高。本研究的目的是寻找预测RS3PE恶性程度的生物标志物。对2007年9月至2019年5月收治的51例RS3PE患者进行了回顾性研究，并进行了长达5年的随访，其中15例为骨性关节炎(OA)，14例为老年性类风湿关节炎(EORA)。采用电化学发光免疫测定法和Luminex人体磁测法测定血清血管生成细胞因子水平。分析临床数据和实验室参数，以确定恶性肿瘤的危险因素。有随访资料的RS3PE患者48例(94.1%)，恶性肿瘤8例(16.7%)，其中血液性肿瘤6例，实体瘤2例。RS3PE恶性组血清碱性成纤维细胞生长因子水平[14.21(7.52，23.18)ng/mL]明显高于非恶性组[4.32(2.88，7.42)ng/mL]、骨质疏松症[3.20(2.20，5.30)ng/mL]和Eora[3.20(2.20，5.30)ng/mL]。碱性成纤维细胞生长因子在RS3PE中判断肿瘤的最佳临界值为10 ng/mL。Logistic回归分析显示，bFGF值升高是RS3PE恶变的危险因素。提示bFGF在RS3PE恶性肿瘤患者中升高，可作为预测副肿瘤性RS3PE的生物标志物。
Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is a rare inflammatory arthritis, with a higher incidence of malignancy. The aim of this study is to identify biomarkers for predicting malignancy in RS3PE. A total of 51 patients with RS3PE from September 2007 to May 2019 were retrospectively reviewed and followed for up to 5 years, with 15 patients with osteoarthritis (OA) and 14 patients with elderly-onset rheumatoid arthritis (EORA) as disease controls. Serum levels of angiogenesis cytokines were measured by electrochemiluminescent immunoassay and Luminex Human Magnetic Assay. Clinical data and laboratory parameters were analyzed to identify risk factors for malignancy. A total of forty-eight RS3PE patients (94.1%) were available with follow-up data; 8 patients (16.7%) were diagnosed with malignancy, of which 6 patients were hematological tumor; and 2 patients were solid tumors. Serum levels of basic fibroblast growth factor (bFGF) were exclusively higher in RS3PE patients with malignancy [14.21 (7.52, 23.18) ng/mL] than RS3PE patients without malignancy [4.32 (2.88, 7.42) ng/mL], OA [3.20 (2.20, 5.30) ng/mL], and EORA [3.20 (2.20, 5.30) ng/mL]. The optimal cut-off value of bFGF for malignancy was 10ng/mL in RS3PE. Logistic regression analysis indicated that elevation of bFGF was a risk factor for malignancy in RS3PE. This study indicated that bFGF was elevated in RS3PE patients with malignancy and could serve as a biomarker for predicting paraneoplastic RS3PE.
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