Antiplatelet resistance in stroke.
Antiplatelet resistance in stroke.
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DOI：
10.1586/ern.10.203
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发表时间：
2011-02
影响因子：
4.3
通讯作者：
Ay H
中科院分区：
文献类型：
--
作者：
Topçuoglu MA;Arsava EM;Ay H
尽管缺血性卒中中抗血小板抵抗的确切患病率尚不清楚，但对两种最广泛使用的抗血小板药物——阿司匹林和氯吡格雷的估计表明，无论使用的定义和测量的参数如何，耐药率都很高。卒中和急性冠状动脉综合征患者抗血小板反应性不足与缺血性血管事件复发风险增加相关。目前尚不清楚基于血小板功能测试结果的定制抗血小板治疗是否转化为预防卒中后继发性血管事件的更有效策略。需要使用普遍接受的抗血小板耐药性定义和标准化测量技术进行大规模临床试验，以证明“血小板功能测试引导的抗血小板治疗”策略是否转化为改善卒中护理。本文概述了实验室抗血小板耐药的临床重要性，描述了血小板功能测试指导抗血小板治疗的挑战，并讨论了有关阿司匹林和/或氯吡格雷耐药患者管理的实际问题。
Although the exact prevalence of antiplatelet resistance in ischemic stroke is not known, estimates about the two most widely used antiplatelet agents – aspirin and clopidogrel – suggest that the resistance rate is high, irrespective of the definition used and parameters measured. Inadequate antiplatelet responsiveness correlates with an increased risk of recurrent ischemic vascular events in patients with stroke and acute coronary syndrome. It is not currently known whether tailoring antiplatelet therapy based on platelet function test results translates into a more effective strategy to prevent secondary vascular events after stroke. Large-scale clinical trials using a universally accepted definition and standardized measurement techniques for antiplatelet resistance are needed to demonstrate whether a ‘platelet-function test-guided antiplatelet treatment’ strategy translates into improved stroke care. This article gives an overview of the clinical importance of laboratory antiplatelet resistance, describes the challenges for platelet-function test-guided antiplatelet treatment and discusses practical issues about the management of patients with aspirin and/or clopidogrel resistance.
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影响因子：
120.7
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影响因子：
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作者：
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通讯作者：
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