Increased hippocampal glutamate and volumetric deficits in unmedicated patients with schizophrenia.
Increased hippocampal glutamate and volumetric deficits in unmedicated patients with schizophrenia.
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DOI：
10.1001/jamapsychiatry.2013.2437
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发表时间：
2013-12
期刊：
影响因子：
25.8
通讯作者：
Lahti AC
中科院分区：
文献类型：
--
作者：
Kraguljac NV;White DM;Reid MA;Lahti AC
谷氨酸能神经传递的背景改变被认为是精神分裂症的关键病理生理机制。目的探讨未服药精神分裂症(SZ)患者的海马区体积测量和神经代谢产物及其相互关系。我们的先验假设是谷氨酸与精神分裂症患者的海马体体积呈负相关。设计结合3T结构磁共振成像和单体素质子磁共振波谱研究。单位：UAB精神病学参与者，27名未用药的SZ和27名健康对照(HC)，主要结果测量，海马区体积测量和神经代谢产物。容量测量与神经代谢物之间的相关性。结果SZ组大鼠海马体质量下降，GLX/Cr值升高，NAA/Cr值与GLX/Cr值失去相关性。SZ组大鼠海马体积测量与GLX/Cr显著相关，而HC组无显著相关性。结论我们的发现支持了在精神分裂症神经影像研究中观察到的海马区结构缺陷可能与海马谷氨酸的改变有关的理论。
CONTEXT Alterations in glutamatergic neurotransmission have been postulated to be a key pathophysiologic mechanism in schizophrenia. OBJECTIVE To evaluate hippocampal volumetric measures and neurometabolites in unmedicated patients with schizophrenia (SZ) and correlations between these markers. Our a priori hypothesis was that glutamate would negatively correlate with hippocampal volume in schizophrenia. DESIGN Combined 3T structural Magnetic Resonance Imaging and single voxel Proton Magnetic Resonance Spectroscopy study. SETTING UAB Psychiatry PARTICIPANTS 27 unmedicated SZ and 27 healthy controls (HC) MAIN OUTCOME MEASURES Hippocampal volumetric measures and neurometabolites. Correlations between volumetric measurements and neurometabolites. RESULTS Hippocampal volumetric deficits, increased hippocampal Glx/Cr, loss of correlation of hippocampal NAA/Cr and Glx/Cr in SZ. Significant correlations between hippocampal volumetric measures and Glx/Cr in SZ but not HC. CONCLUSION Our findings support the theory that alterations in hippocampal glutamate potentially account for structural deficits in the hippocampus observed in schizophrenia neuroimaging studies.
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DOI：
10.1007/s00406-003-0398-5
发表时间：
2003-02-01
影响因子：
4.7
作者：
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作者：
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TAMMINGA, CA