The interhemispheric connections of the striatum: Implications for Parkinson's disease and drug-induced dyskinesias.
The interhemispheric connections of the striatum: Implications for Parkinson's disease and drug-induced dyskinesias.
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DOI：
10.1016/j.brainresbull.2011.09.013
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发表时间：
2012-01-04
影响因子：
3.8
通讯作者：
Subramanian T
中科院分区：
文献类型：
--
作者：
Lieu CA;Subramanian T
帕金森病（PD）的特征是黑质纹状体神经元的丧失和多巴胺的消耗。这种病理特征导致基底神经节回路的改变和随后的运动障碍。药物多巴胺替代疗法如左旋多巴可以改善帕金森病的症状，但可能导致运动并发症，即药物性运动障碍。我们最近的研究表明，尽管慢性间歇性暴露和单侧黑质纹状体神经元和多巴胺的显著丧失，临床上的半帕金森性恒河猴不会发生左旋多巴诱导的运动障碍。目前尚不清楚是什么机制阻止了这些动物运动障碍的发生。然而，根据我们的研究以及之前在大鼠和猴子PD模型中的损伤研究结果，我们假设在这些动物中预防运动障碍发生的一种潜在机制是半球间抑制。两个可能调节运动障碍的半球间连接是半球间黑质纹状体和皮质纹状体通路。很少有研究者研究大脑半球间黑质纹状体和皮质纹状体的连接及其在帕金森病药物性运动障碍中可能发挥的功能作用。因此，在下面的综述中，我们评估这些半球间连接的神经解剖学、电生理和行为特性。未来的研究评估这些半球间纹状体通路和这些通路在运动障碍状态下发生的病理生理变化，有必要进一步开发预防或减轻PD药物性运动障碍的治疗方法。
Parkinson’s disease (PD) is characterized by loss of nigrostriatal neurons and depletion of dopamine. This pathological feature leads to alterations to basal ganglia circuitry and subsequent motor disability. Pharmacological dopamine replacement therapy with medications such as levodopa ameliorates the symptoms of PD but can lead to motor complications known as drug-induced dyskinesias. We have recently shown that clinically hemiparkinsonian rhesus monkeys do not develop levodopa-induced dyskinesias despite chronic intermittent exposure and significant unilateral loss of nigrostriatal neurons and dopamine. It is currently unclear what mechanisms prevent the onset of dyskinesias in these animals. However, based on our study and results from previous lesioning studies in both the rat and monkey models of PD, we hypothesize that one potential mechanism that may prevent the genesis of dyskinesias in these animals is interhemispheric inhibition. Two potential interhemispheric connections that may modulate dyskinesias are the interhemispheric nigrostriatal and corticostriatal pathways. Few investigators have examined the interhemispheric nigrostriatal and corticostriatal connections and the functional role they may play in drug-induced dyskinesias in PD. Therefore, in the following review, we assess the neuroanatomical, electrophysiological and behavioral properties of these interhemispheric connections. Future studies evaluating these interhemispheric striatal pathways and the pathophysiological changes that occur to these pathways in the dyskinetic state are warranted to further develop treatments that prevent or mitigate drug-induced dyskinesias in PD.
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影响因子：
3.3
作者：
FRANCOIS, C;PERCHERON, G;YELNIK, J
通讯作者：
YELNIK, J
影响因子：
5.3
作者：
COSPITO, JA;KULTASILINSKY, K
通讯作者：
KULTASILINSKY, K
影响因子：
11.2
作者：
Kordower, Jeffrey H.;Herzog, Christopher D.;Bartus, Raymond T.
通讯作者：
Bartus, Raymond T.
影响因子：
2.5
作者：
JAEGER, CB;JOH, TH;REIS, DJ
通讯作者：
REIS, DJ
DOI：
10.1007/bf01972287
发表时间：
1982-01-01
期刊：
EXPERIENTIA
影响因子：
--
作者：
COLLINGRIDGE, GL
通讯作者：
COLLINGRIDGE, GL