Translating the frontiers of brain repair to treatments: starting not to break the rules.
Translating the frontiers of brain repair to treatments: starting not to break the rules.
复制标题
DOI：
10.1016/j.nbd.2009.09.005
复制
发表时间：
2010-02
影响因子：
6.1
通讯作者：
Carmichael ST
中科院分区：
文献类型：
--
作者：
Carmichael ST
中风中的神经修复领域已经确定了重组的细胞系统和可能的分子机制。现在，概念障碍限制了临床有用药物的产生。首先，目前尚不清楚中风中神经修复的因果机制是什么。其次，需要确定候选分子的神经修复药物的适当递送系统。第三，现有的药理学药物，提高注意力，情绪或唤醒中风的临时应用已经失败。专门利用学习和记忆分子系统的新方法为中风修复药物提供了新的途径。第四，临床治疗需要考虑神经修复的组合治疗。最后，神经修复疗法的目标是改变大脑连接、认知地图和活跃的神经网络。这些行为可能会引发一系列独特的“神经修复副作用”，需要在计划临床试验时加以考虑。
The field of neural repair in stroke has identified cellular systems of reorganization and possible molecular mechanisms. Conceptual barriers now limit the generation of clinically useful agents. First, it is not clear what the causal mechanisms of neural repair are in stroke. Second, adequate delivery systems for neural repair drugs need to be determined for candidate molecules. Third, ad hoc applications of existing pharmacological agents that enhance attention, mood or arousal to stroke have failed. New approaches that specifically harness the molecular systems of learning and memory provide a new avenue for stroke repair drugs. Fourth, combinatorial treatments for neural repair need to be considered for clinical therapies. Finally, neural repair therapies have as a goal altering brain connections, cognitive maps and active neural networks. These actions may trigger a unique set of “neural repair side effects” that need to be considered in planning clinical trials.
登录
查看更多内容
影响因子：
6.1
作者：
Benowitz LI;Carmichael ST
通讯作者：
Carmichael ST
影响因子：
5.3
作者：
Bitner, Robert S.;Bunnelle, William H.;Gopalakrishnan, Murali
通讯作者：
Gopalakrishnan, Murali
影响因子：
16.2
作者：
Conner, JM;Chiba, AA;Tuszynski, MH
通讯作者：
Tuszynski, MH
影响因子：
2.7
作者：
Arami, S;Jucker, M;Welzl, H
通讯作者：
Welzl, H
影响因子：
16.2
作者：
Ferezou, Isabelle;Haiss, Florent;Petersen, Carl C. H.
通讯作者：
Petersen, Carl C. H.