Sex differences in drug-related stress-system changes: implications for treatment in substance-abusing women.
Sex differences in drug-related stress-system changes: implications for treatment in substance-abusing women.
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DOI：
10.1080/10673220902899680
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发表时间：
2009
影响因子：
3.8
通讯作者：
Sinha R
中科院分区：
文献类型：
--
作者：
Fox HC;Sinha R
广泛的研究表明，长期滥用药物会破坏大脑的压力和奖励系统。这些压力系统的变化，包括性激素对这些变化的影响，性别差异，可能会影响性别特异性差异的发展，并恢复，依赖。因此，压力系统功能的性别差异也可以为为什么妇女比男子更容易受到吸毒的负面影响提供一个可行的解释。因此，本文首先回顾了研究，研究了性别差异的情绪和生物生理变化的压力和奖励系统后，急性管理的药物，包括可卡因，酒精和尼古丁。然后，文章回顾了研究，研究了健康和药物滥用人群中各种类型的压力反应的性别差异。研究检查性激素对这些与性别有关的反应的影响也有报道。这些性别特异性的压力和奖励系统功能的变化的影响进行了讨论，共病的精神病理学和治疗结果。
Extensive research indicates that chronic substance abuse disrupts stress and reward systems of the brain. Gender variation within these stress-system alterations, including the impact of sex hormones on these changes, may influence sex-specific differences in both the development of, and recovery from, dependency. As such, gender variations in stress-system function may also provide a viable explanation for why women are markedly more vulnerable than men to the negative consequences of drug use. This article therefore initially reviews studies that have examined gender differences in emotional and biophysiological changes to the stress and reward system following the acute administration of drugs, including cocaine, alcohol, and nicotine. The article then reviews studies that have examined gender differences in response to various types of stress in both healthy and drug-abusing populations. Studies examining the impact of sex hormones on these gender-related responses are also reported. The implications of these sex-specific variations in stress and reward system function are discussed in terms of both comorbid psychopathology and treatment outcome.
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DOI：
10.1097/01.alc.0000153544.83656.3c
发表时间：
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影响因子：
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DOI：
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发表时间：
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影响因子：
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