Default mode network in young male adults with autism spectrum disorder: relationship with autism spectrum traits.
Default mode network in young male adults with autism spectrum disorder: relationship with autism spectrum traits.
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DOI：
10.1186/2040-2392-5-35
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发表时间：
2014
期刊：
影响因子：
6.2
通讯作者：
Iidaka T
中科院分区：
文献类型：
--
作者：
Jung M;Kosaka H;Saito DN;Ishitobi M;Morita T;Inohara K;Asano M;Arai S;Munesue T;Tomoda A;Wada Y;Sadato N;Okazawa H;Iidaka T
自闭症谱系特征被认为存在于自闭症个体和典型发育个体（TD）之间的连续统一体上。与自闭症谱系特征密切相关的社会认知特性与大脑默认模式网络（DMN）区域之间的功能连接有关。已有研究表明，自闭症谱系障碍（ASD）患者的静息状态功能连接（rs-FCs）较低，且与自闭症谱系特征水平呈负相关。然而，目前尚不清楚自闭症谱系特征的个体差异是否与包括一般人群在内的参与者的DMN的rs-FCs强度有关。采用基于种子的方法，我们研究了19例年轻男性高功能ASD患者DMN的rs- fc，特别是DMN的两个核心区域：前内侧前额叶皮层（aMPFC）和后扣带皮层（PCC）(平均年龄= 25.3±6.9岁；全量表智商(F-IQ) = 109.7±12.4)与TD组21名年龄和智商匹配的年轻成年男性（平均年龄= 24.8±4.3岁；AQ = 18.6±5.7;F-IQ = 109.5±8.7）进行比较。我们还分析了rs-FCs强度与使用AQ评分测量的自闭症谱系特征之间的相关性。来自DMN核心区域的rs- fc在ASD参与者中的强度显著低于TD参与者。经多元回归分析，aMPFC种子脑区rs- fc强度与ASD和TD受试者的AQ评分呈负相关。我们的研究结果表明，DMN中rs-FCs的强度与TD人群和ASD患者的自闭症谱系特征有关，支持连续体观点。DMN的rs- fc可能是客观识别自闭症谱系特征的有用生物标志物，与ASD诊断无关。
Autism spectrum traits are postulated to lie on a continuum that extends between individuals with autism and individuals with typical development (TD). Social cognition properties that are deeply associated with autism spectrum traits have been linked to functional connectivity between regions within the brain’s default mode network (DMN). Previous studies have shown that the resting-state functional connectivities (rs-FCs) of DMN are low and show negative correlation with the level of autism spectrum traits in individuals with autism spectrum disorder (ASD). However, it is unclear whether individual differences of autism spectrum traits are associated with the strength of rs-FCs of DMN in participants including the general population. Using the seed-based approach, we investigated the rs-FCs of DMN, particularly including the following two core regions of DMN: the anterior medial prefrontal cortex (aMPFC) and posterior cingulate cortex (PCC) in 19 young male adults with high-functioning ASD (mean age = 25.3 ± 6.9 years; autism-spectrum quotient (AQ) = 33.4 ± 4.2; full scale IQ (F-IQ) = 109.7 ± 12.4) compared with 21 age- and IQ-matched young male adults from the TD group (mean age = 24.8 ± 4.3 years; AQ = 18.6 ± 5.7; F-IQ = 109.5 ± 8.7). We also analyzed the correlation between the strength of rs-FCs and autism spectrum traits measured using AQ score. The strengths of rs-FCs from core regions of DMN were significantly lower in ASD participants than TD participants. Under multiple regression analysis, the strengths of rs-FCs in brain areas from aMPFC seed showed negative correlation with AQ scores in ASD participants and TD participants. Our findings suggest that the strength of rs-FCs in DMN is associated with autism spectrum traits in the TD population as well as patients with ASD, supporting the continuum view. The rs-FCs of DMN may be useful biomarkers for the objective identification of autism spectrum traits, regardless of ASD diagnosis.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
DOI：
10.1097/01.chi.0000046811.95464.21
发表时间：
2003-04-01
影响因子：
13.3
作者：
Constantino, JN;Hudziak, JJ;Todd, RD
通讯作者：
Todd, RD
影响因子：
3.3
作者：
Joel, Suresh E.;Caffo, Brian S.;van Zijl, Peter C. M.;Pekar, James J.
通讯作者：
Pekar, James J.
影响因子：
2.5
作者：
Ishitobi, Makoto;Kosaka, Hirotaka;Wada, Yuji
通讯作者：
Wada, Yuji
影响因子：
16.2
作者：
Andrews-Hanna, Jessica R.;Reidler, Jay S.;Sepulcre, Jorge;Poulin, Renee;Buckner, Randy L.
通讯作者：
Buckner, Randy L.