Sex-specific enhancement of palatability-driven feeding in adolescent rats.
Sex-specific enhancement of palatability-driven feeding in adolescent rats.
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DOI：
10.1371/journal.pone.0180907
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Ostlund SB
中科院分区：
文献类型：
--
作者：
Marshall AT;Liu AT;Murphy NP;Maidment NT;Ostlund SB
据推测，青春期的大脑发育扰乱了奖励过程，最终可能导致与这一阶段相关的危险决策，特别是在年轻男性中。为了研究青春期潜在的奖励功能障碍，实验1研究了大鼠的适口性液体摄入量与年龄和性别的关系。在一系列每周两次的测试期间，非食物剥夺大鼠有机会自愿食用高度可口的甜炼乳（SCM）溶液。我们发现，青春期的雄性大鼠（而不是雌性大鼠）在青春期前后表现出明显的、短暂的SCM摄入量增加（按体重标准化）。此外，成年女性消耗更多的SCM比成年男性和青春期女性。使用一个完善的分析框架来解析奖励适口性和饱腹感对摄食行为时间结构的影响，我们发现，相对于其他组，青少年男性在进餐开始时的适口性驱动摄入量显着升高。此外，尽管我们发现在饱腹感的发生方面存在一些群体差异，但它们不太可能导致摄入量的差异。实验2证实，即使使用无热量糖精溶液作为味觉刺激，青春期雄性大鼠相对于成年雄性表现出可口液体消耗量升高，这表明这些结果不太可能与代谢需求的年龄相关差异有关。这些发现表明，青春期可口食物摄入量的增加是性别特异性的，并受到奖励处理的根本变化的驱动。由于青少年的冒险行为被假设为对食欲刺激的敏感性和高估的潜在结果，奖励适口性的个体差异可能会影响青少年风险决策的个体差异。
It has been hypothesized that brain development during adolescence perturbs reward processing in a way that may ultimately contribute to the risky decision making associated with this stage of life, particularly in young males. To investigate potential reward dysfunction during adolescence, Experiment 1 examined palatable fluid intake in rats as a function of age and sex. During a series of twice-weekly test sessions, non-food-deprived rats were given the opportunity to voluntarily consume a highly palatable sweetened condensed milk (SCM) solution. We found that adolescent male, but not female, rats exhibited a pronounced, transient increase in SCM intake (normalized by body weight) that was centered around puberty. Additionally, adult females consumed more SCM than adult males and adolescent females. Using a well-established analytical framework to parse the influences of reward palatability and satiety on the temporal structure of feeding behavior, we found that palatability-driven intake at the outset of the meal was significantly elevated in adolescent males, relative to the other groups. Furthermore, although we found that there were some group differences in the onset of satiety, they were unlikely to contribute to differences in intake. Experiment 2 confirmed that adolescent male rats exhibit elevated palatable fluid consumption, relative to adult males, even when a non-caloric saccharin solution was used as the taste stimulus, demonstrating that these results were unlikely to be related to age-related differences in metabolic need. These findings suggest that elevated palatable food intake during adolescence is sex specific and driven by a fundamental change in reward processing. As adolescent risk taking has been hypothesized as a potential result of hypersensitivity to and overvaluation of appetitive stimuli, individual differences in reward palatability may factor into individual differences in adolescent risky decision making.
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影响因子：
2.9
作者：
Davis, JD;Breslin, PAS
通讯作者：
Breslin, PAS
影响因子：
5.4
作者：
DAVIS, JD;LEVINE, MW
通讯作者：
LEVINE, MW
影响因子：
1.7
作者：
Andersen, SL;Rutstein, M;Teicher, MH
通讯作者：
Teicher, MH
影响因子：
2.9
作者：
DAVIS, JD;KUNG, TM;ROSENAK, R
通讯作者：
ROSENAK, R
DOI：
10.1037/h0031388
发表时间：
1971-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
ALLISON, J
通讯作者：
ALLISON, J