An exploratory study on 99mTc-RGD-BBN peptide scintimammography in the assessment of breast malignant lesions compared to 99mTc-3P4-RGD2.
An exploratory study on 99mTc-RGD-BBN peptide scintimammography in the assessment of breast malignant lesions compared to 99mTc-3P4-RGD2.
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与 99mTc-3P4-RGD2 相比，99mTc-RGD-BBN 肽闪烁放射成像在评估乳腺恶性病变中的探索性研究。
DOI：
10.1371/journal.pone.0123401
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Gao S
中科院分区：
文献类型：
--
作者：
Chen Q;Ma Q;Chen M;Chen B;Wen Q;Jia B;Wang F;Sun B;Gao S
本研究旨在探讨新型放射性示踪剂99mTc-RGD-BBN在单光子发射计算机断层扫描/计算机断层扫描（SPECT/CT）对乳腺恶性肿瘤的诊断效果，并与99mTc-3P4-RGD2进行比较。本研究纳入6例经细针穿刺细胞学活检（FNAB）诊断为乳腺恶性肿瘤并计划行手术治疗的女性患者。99mTc-3P4-RGD2和99mTc-RGD-BBN分别于当日静脉注射放射性示踪剂299±30 MBq和293±32 MBq后1小时进行单光子发射计算机断层扫描（SPECT）。以肿瘤与非肿瘤比值（T/NT）评价结果。99mTc-RGD-BBN和99mTc-3P4-RGD2 SPECT/CT图像由3名经验丰富的核医学医生使用3分制系统独立解释。采用免疫组织化学方法检测整联素αvβ3和胃泌素释放肽受体（GRPR）的表达。对99mTc-RGD-BBN在健康志愿者中的安全性、生物分布和辐射剂量学进行了评价。在研究期间，没有任何患者报告严重的不良事件。有效辐射剂量完全符合有关标准。99mTc-RGD-BBN SPECT/CT共检出6个可触及的恶性病变，摄取清晰。采用99mTc-3P4-RGD2 SPECT/CT检测所有恶性病变。结果显示，5个恶性病变有明显的摄取，1个几乎没有摄取。同时表达αvβ3和GRPR的恶性肿瘤4例，仅GRPR阳性表达1例（整合素αvβ3阴性），仅整合素αvβ3阳性表达1例（GRPR阴性）。99mTc-RGD-BBN是一种安全的乳腺癌检测试剂。99mTc-RGD-BBN可能有潜力弥补99mTc-3P4-RGD2在仅GRPR阳性表达（整合素αvβ3阴性）的乳腺癌检测中的不足。99mTc-RGD-BBN的初步应用显示了其在乳腺癌诊断和治疗中的强大潜力。
This study aimed to explore the diagnostic performance of single photon emission computed tomography / computerized tomography (SPECT/CT) using a new radiotracer 99mTc-RGD-BBN for breast malignant tumor compared with 99mTc-3P4-RGD2. 6 female patients with breast malignant tumors diagnosed by fine needle aspiration cytology biopsy (FNAB) who were scheduled to undergo surgery were included in the study. 99mTc-3P4-RGD2 and 99mTc-RGD-BBN were performed with single photon emission computed tomography (SPECT) at 1 hour after intravenous injection of 299 ± 30 MBq and 293 ± 32 MBq of radiotracers respectively at separate day. The results were evaluated by the Tumor to non-Tumor ratios (T/NT). 99mTc-RGD-BBN and 99mTc-3P4-RGD2 SPECT/CT images were interpreted independently by 3 experienced nuclear medicine physicians using a 3-point scale system. All of the samples were analyzed immunohistochemically to evaluate the integrin αvβ3 and gastrin-releasing peptide receptor (GRPR) expression. The safety, biodistribution and radiation dosimetry of 99mTc-RGD-BBN were also evaluated in the healthy volunteers. No serious adverse events were reported in any of the patients during the study. The effective radiation dose entirely conformed to the relevant standards. A total of 6 palpable malignant lesions were detected using 99mTc-RGD-BBN SPECT/CT with clear uptake. All malignant lesions were also detected using 99mTc-3P4-RGD2 SPECT/CT. The results showed that five malignant lesions were with clear uptake and the other one with barely an uptake. 4 malignant cases were found with both αvβ3 and GRPR expression, 1 case with only GRPR positive expression (integrin αvβ3 negative) and 1 case with only integrin αvβ3 positive expression (GRPR negative). 99mTc-RGD-BBN is a safe agent for detecting breast cancer. 99mTc-RGD-BBN may have the potential to make up for the deficiency of 99mTc-3P4-RGD2 in the detection of breast cancer with only GRPR positive expression (integrin αvβ3 negative). The preliminary application of 99mTc-RGD-BBN has demonstrated its powerful potential in breast cancer diagnosis and therapy.
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影响因子：
7.4
作者：
Liu, Zhiming;Hu, Chaofan;Guo, Zhouyi
通讯作者：
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DOI：
10.1007/s00259-009-1123-z
发表时间：
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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