Circadian clocks, rhythmic synaptic plasticity and the sleep-wake cycle in zebrafish.
Circadian clocks, rhythmic synaptic plasticity and the sleep-wake cycle in zebrafish.
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DOI：
10.3389/fncir.2013.00009
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发表时间：
2013
影响因子：
3.5
通讯作者：
Appelbaum L
中科院分区：
文献类型：
--
作者：
Elbaz I;Foulkes NS;Gothilf Y;Appelbaum L
生物钟和自我平衡过程是调节睡眠的基本机制。令人惊讶的是，尽管经过几十年的研究，我们仍然不知道我们为什么睡觉。有趣的假说表明，睡眠调节突触可塑性，因此在学习和记忆中具有有益的作用。然而，直接证据仍然有限，分子调控机制仍不清楚。斑马鱼提供了一个强大的脊椎动物模型系统，可以进行简单的遗传操作，对活体动物的神经元回路和突触进行成像，并监测白天和晚上的行为表现。因此，斑马鱼已成为研究调节睡眠的昼夜节律和稳态过程的有吸引力的模型。斑马鱼的时钟和睡眠相关基因已经被克隆，表现出昼夜节律的活动和突触可塑性的神经元回路已经被研究，并有节奏的行为输出的特点。这些数据的整合可以更好地理解睡眠调节。本文综述了斑马鱼生物钟和睡眠的研究进展，重点介绍了调节褪黑素分泌节律、结构突触可塑性、运动活动和睡眠的遗传和神经内分泌机制。
The circadian clock and homeostatic processes are fundamental mechanisms that regulate sleep. Surprisingly, despite decades of research, we still do not know why we sleep. Intriguing hypotheses suggest that sleep regulates synaptic plasticity and consequently has a beneficial role in learning and memory. However, direct evidence is still limited and the molecular regulatory mechanisms remain unclear. The zebrafish provides a powerful vertebrate model system that enables simple genetic manipulation, imaging of neuronal circuits and synapses in living animals, and the monitoring of behavioral performance during day and night. Thus, the zebrafish has become an attractive model to study circadian and homeostatic processes that regulate sleep. Zebrafish clock- and sleep-related genes have been cloned, neuronal circuits that exhibit circadian rhythms of activity and synaptic plasticity have been studied, and rhythmic behavioral outputs have been characterized. Integration of this data could lead to a better understanding of sleep regulation. Here, we review the progress of circadian clock and sleep studies in zebrafish with special emphasis on the genetic and neuroendocrine mechanisms that regulate rhythms of melatonin secretion, structural synaptic plasticity, locomotor activity and sleep.
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DOI：
10.1126/science.1166673
发表时间：
2009-04-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Gilestro GF;Tononi G;Cirelli C
通讯作者：
Cirelli C
影响因子：
9.8
作者：
Cirelli C;Tononi G
通讯作者：
Tononi G
影响因子：
3.5
作者：
Hurd, MW;Cahill, GM
通讯作者：
Cahill, GM
昼夜节律的代谢和能量学的融合。
DOI：
10.1126/science.1195027
发表时间：
2010-12-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bass J;Takahashi JS
通讯作者：
Takahashi JS
影响因子：
34.7
作者：
Cirelli, Chiara
通讯作者：
Cirelli, Chiara