Pallidal stimulation: effect of pattern and rate on bradykinesia in the non-human primate model of Parkinson's disease.
Pallidal stimulation: effect of pattern and rate on bradykinesia in the non-human primate model of Parkinson's disease.
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DOI：
10.1016/j.expneurol.2011.06.012
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发表时间：
2011-10
影响因子：
5.3
通讯作者：
Vitek, Jerrold L.
中科院分区：
文献类型：
--
作者：
Baker, Kenneth B.;Zhang, Jianyu;Vitek, Jerrold L.
关键词：
脑深部电刺激（DBS）涉及向特定脑区输送连续、固定频率的电脉冲;然而，目前尚不清楚治疗受益对刺激模式固定频率性质的依赖性。为了解决这个问题，我们研究了在一个单一的，偏侧帕金森病猴的运动迟缓的苍白球（GPi）的内部段DBS的模式和频率的变化的影响。治疗参数（即，接触、脉冲宽度、幅度），基于在到达和取回任务期间改进的运动时间，建立135 Hz的固定频率刺激。此后，改变刺激的模式和频率以评估刺激的可变性、爆发和振荡模式对运动迟缓的影响。在固定频率刺激期间，性能作为增加脉冲率的函数而改善（p < 0.01）。在相同的平均频率下使用时间上不规则的模式未能改变相对于固定频率条件的治疗益处。相对于“关闭”和80 Hz固定频率条件，引入80 Hz脉冲串模式（20脉冲串/秒，4脉冲/脉冲串）改善了运动迟缓（p < 0.01），产生了与135 Hz固定频率刺激相当的结果，电流消耗减少40%。与爆发和固定频率刺激相比，4和8 Hz的振荡模式效果较差。这些结果表明，以规则爆发模式递送的较低频率刺激可能同样有效，并且需要比较高频率连续刺激模式更低的能量，从而延长电池寿命，并质疑爆发活动在运动迟缓发病机制中的作用。
Deep brain stimulation (DBS) involves the delivery of continuous, fixed-frequency electrical pulses to specific brain regions; however the reliance of therapeutic benefit on the fixed-frequency nature of the stimulation pattern is currently unknown. To address this, we investigated the effect of changes in the pattern and frequency of DBS in the internal segment of the globus pallidus (GPi) on bradykinesia in a single, hemi-parkinsonian monkey. Therapeutic parameters (i.e., contacts, pulse width, amplitude) were established for fixed-frequency stimulation at 135 Hz based on improved movement times during a reach and retrieval task. Thereafter, the pattern and frequency of stimulation was varied to assess the effect of variability, bursting and oscillatory patterns of stimulation on bradykinesia. During fixed-frequency stimulation, performance improved as a function of increasing pulse rate (p < 0.01). Using a temporally irregular pattern at the same average frequency failed to alter therapeutic benefit relative to the fixed-frequency condition. Introducing an 80 Hz burst pattern (20 bursts/second at 4 pulses/burst) improved bradykinesia (p < 0.01) relative to both “OFF” and 80 Hz fixed-frequency conditions, yielding results comparable to fixed-frequency stimulation at 135 Hz with 40% less current drain. Compared to burst and fixed-frequency stimulation, oscillatory patterns at 4 and 8 Hz were less effective. These results suggest that lower frequency stimulation delivered in a regular bursting pattern may be equally effective and require lower energy than higher frequency continuous patterns of stimulation, thereby prolonging battery life and call into question the role of bursting activity in the pathogenesis of bradykinesia.
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影响因子：
5.3
作者：
Xu, Weidong;Russo, Gary S.;Hashimoto, Takao;Zhang, Jianyu;Vitek, Jerrold L.
通讯作者：
Vitek, Jerrold L.
影响因子：
1.7
作者：
Birdno, Merrill J.;Kuncel, Alexis M.;Grill, Warren M.
通讯作者：
Grill, Warren M.
影响因子：
3
作者：
Kaneoke, Y;Vitek, JL
通讯作者：
Vitek, JL
影响因子：
2.5
作者：
Fogelson, N;Kühn, AA;Brown, P
通讯作者：
Brown, P
DOI：
10.1111/j.1749-6632.1988.tb32998.x
发表时间：
1988-01-18
影响因子：
5.2
作者：
MILLER, WC;DELONG, MR
通讯作者：
DELONG, MR