Examining the impact of neuroimmune dysregulation on social behavior of male and female juvenile rats.
Examining the impact of neuroimmune dysregulation on social behavior of male and female juvenile rats.
复制标题
检查神经免疫失调对男性和女性少年大鼠社会行为的影响。
DOI：
10.1016/j.bbr.2021.113449
复制
发表时间：
2021-10-11
影响因子：
2.7
通讯作者：
Schwarz JM
中科院分区：
文献类型：
--
作者：
Turano A;McAuley EM;Muench MC;Schwarz JM
许多被诊断患有神经精神障碍的个体，如自闭症、注意力缺陷/多动障碍、精神分裂症和社交焦虑障碍，都有一个共同的异常社交行为维度。流行病学数据表明，不利的环境因素有助于神经发育障碍的风险，包括那些与异常的社会行为。早期接触传染性病原体是这些不利的环境因素之一，这表明在早期发育期间免疫系统的激活可能有助于与改变的社会行为相关的疾病病理学。在目前的项目中，我们研究了新生儿感染的影响，有或没有青少年免疫激活，青少年社会行为的表达和表达的炎性细胞因子和小胶质细胞信号分子在幼年大鼠大脑。这些实验的结果表明，新生儿感染显着减少青少年的社会互动，但显着增加青少年的游戏行为在男性和女性的大鼠。此外，单独的新生儿感染，单独的幼年免疫激活，以及新生儿感染加上幼年免疫激活都显着损害了幼年雄性大鼠的社会识别。幼年雌性大鼠（包括对照组）未能表现出社会识别，在我们的三室社会识别测试。综上所述，本文提供的行为和分子数据支持发育中的大脑对免疫激活的敏感性，特别是在表达与年龄相适应的社会行为方面。这些数据保证了额外研究的设计，以检查早期生命免疫激活和异常社会行为之间的机制关系，以开发新的以及修改现有的治疗靶点和预防措施，以帮助那些表现出异常社会行为的人。
Many individuals diagnosed with neuropsychiatric disorders, such as autism, attention-deficit/hyperactivity disorder, schizophrenia, and social anxiety disorder, all share a common dimension of aberrant social behavior. Epidemiological data indicate that adverse environmental factors contribute to the risk for neurodevelopmental disorders, including those associated with aberrant social behavior. Early-life exposure to infectious pathogens is one of those adverse environmental factors, suggesting that activation of the immune system during early development may contribute to disease pathology associated with altered social behavior. In the current project, we examined the impact of neonatal infection, with or without juvenile immune activation, on the expression of juvenile social behavior and on the expression of inflammatory cytokines and microglial signaling molecules in the juvenile rat brain. The outcomes of these experiments revealed that neonatal infection significantly decreased juvenile social interaction, but significantly increased juvenile play behavior in male and female rats. Moreover, neonatal infection alone, juvenile immune activation alone, and neonatal infection plus juvenile immune activation all significantly impaired social recognition in juvenile male rats. Juvenile female rats (including controls) failed to demonstrate social recognition as measured in our three-chamber social recognition test. Taken together, the behavioral and molecular data presented here support the sensitivity of the developing brain to immune activation, particularly in the expression of age-appropriate social behaviors. These data warrant the design of additional studies to examine the mechanistic relationship between early-life immune activation and aberrant social behavior to develop novel as well as modify existing therapeutic targets and preventative measures to help those who display aberrant social behavior.
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影响因子：
8.7
作者：
Dinarello CA
通讯作者：
Dinarello CA
DOI：
10.1073/pnas.1005003107
发表时间：
2010-11-23
影响因子：
11.1
作者：
Krebs-Kraft, Desiree L.;Hill, Matthew N.;McCarthy, Margaret M.
通讯作者：
McCarthy, Margaret M.
影响因子：
3.3
作者：
Eisenberger NI
通讯作者：
Eisenberger NI
影响因子：
3
作者：
Bilbo SD;Schwarz JM
通讯作者：
Schwarz JM
影响因子：
8.2
作者：
Beery AK;Zucker I
通讯作者：
Zucker I