An orderly sequence of autonomic and neural events at transient arousal changes.
An orderly sequence of autonomic and neural events at transient arousal changes.
复制标题
DOI：
10.1016/j.neuroimage.2022.119720
复制
发表时间：
2022-12-01
期刊：
影响因子：
5.7
通讯作者：
Liu, Xiao
中科院分区：
文献类型：
--
作者：
Gu, Yameng;Han, Feng;Sainburg, E. Lucas;Schade, M. Margeaux;Buxton, M. Orfeu;Duyn, H. Jeff;Liu, Xiao
静息状态功能磁共振成像（rsfMRI）允许基于神经元活动的空间结构变化研究功能性脑连接。正确评估连通性需要去除fMRI信号的非神经贡献，特别是与自主神经变异性相关的血流动力学变化。基于自主神经指示信号的回归分析已用于此目的，但如果神经元和自主神经活动共同变化，则可能不充分。为了研究这种潜在的共变异，我们进行了rsfMRI实验，同时获取脑电图（EEG）和自主神经指标信号，包括心率、呼吸深度和外周血管张力。我们确定了fMRI的周期性和系统性时空模式（称为fMRI级联），其特征是显著性和默认模式网络以及丘脑的短暂信号减少，随后是感觉-运动主导的双相全球变化。这种fMRI级联，主要是在闭眼状态下观察到的，伴随着大量的脑电图和表明觉醒调节的自主神经变化。重要的是，从rsfMRI中去除fMRI级联动力学减弱了其与各种信号的相关性。这些结果表明，rsfMRI与各种生理和神经信号的相关性不是独立的，而是至少部分地源于fMRI级联以及唤醒调节时相关的神经和生理变化。
Resting-state functional magnetic resonance imaging (rsfMRI) allows the study of functional brain connectivity based on spatially structured variations in neuronal activity. Proper evaluation of connectivity requires removal of non-neural contributions to the fMRI signal, in particular hemodynamic changes associated with autonomic variability. Regression analysis based on autonomic indicator signals has been used for this purpose, but may be inadequate if neuronal and autonomic activities covary. To investigate this potential co-variation, we performed rsfMRI experiments while concurrently acquiring electroencephalography (EEG) and autonomic indicator signals, including heart rate, respiratory depth, and peripheral vascular tone. We identified a recurrent and systematic spatiotemporal pattern of fMRI (named as fMRI cascade), which features brief signal reductions in salience and default-mode networks and the thalamus, followed by a biphasic global change with a sensory-motor dominance. This fMRI cascade, which was mostly observed during eyes-closed condition, was accompanied by large EEG and autonomic changes indicative of arousal modulations. Importantly, the removal of the fMRI cascade dynamics from rsfMRI diminished its correlations with various signals. These results suggest that the rsfMRI correlations with various physiological and neural signals are not independent but arise, at least partly, from the fMRI cascades and associated neural and physiological changes at arousal modulations.
登录
查看更多内容
影响因子：
5.7
作者：
Chang C;Metzger CD;Glover GH;Duyn JH;Heinze HJ;Walter M
通讯作者：
Walter M
影响因子：
4.8
作者：
Birn, Rasmus M.;Murphy, Kevin;Bandettini, Peter A.
通讯作者：
Bandettini, Peter A.
DOI：
10.1098/rstb.2019.0635
发表时间：
2021-01-04
影响因子：
6.3
作者：
Das, Aniruddha;Murphy, Kevin;Drew, Patrick J.
通讯作者：
Drew, Patrick J.
影响因子：
5.7
作者：
Britz, Juliane;Van De Ville, Dimitri;Michel, Christoph M.
通讯作者：
Michel, Christoph M.
影响因子：
--
作者：
Berger, H
通讯作者：
Berger, H