Association between heart rate variability and fluctuations in resting-state functional connectivity.
Association between heart rate variability and fluctuations in resting-state functional connectivity.
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DOI：
10.1016/j.neuroimage.2012.11.038
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发表时间：
2013-03
期刊：
影响因子：
5.7
通讯作者：
Walter M
中科院分区：
文献类型：
--
作者：
Chang C;Metzger CD;Glover GH;Duyn JH;Heinze HJ;Walter M
已经观察到功能连接在静息状态扫描的过程中波动，尽管这种现象的起源和功能相关性仍有待证明。本研究探讨了闭眼休息条件下功能连接的内源性动力学与自主神经状态之间的联系。使用滑动窗口分析静息状态的功能磁共振成像数据从35个年轻的，健康的男性受试者，我们研究了心率变异性（HRV）如何协变与时间变化的全脑功能连接与种子区域先前描述的介导的警觉和觉醒的影响（杏仁核和背侧前扣带皮层; dACC）。我们确定了一组区域，包括脑干、丘脑、壳核和背外侧前额叶皮层，在心率变异性升高的状态下，这些区域与dACC和杏仁核种子的耦合更加强烈。HRV的高频和低频分量之间的影响不同，这表明副交感神经和交感神经张力对个体连接的具体贡献。此外，功能连接的动力学可以从主要与BOLD信号波动相关的动力学中分离出来。目前的研究结果有助于新的信息自主神经系统状态的瞬态变化的神经基础，并建议最近观察到的非平稳性在静息状态功能连接的生理和心理成分。
Functional connectivity has been observed to fluctuate across the course of a resting state scan, though the origins and functional relevance of this phenomenon remain to be shown. The present study explores the link between endogenous dynamics of functional connectivity and autonomic state in an eyes-closed resting condition. Using a sliding window analysis on resting state fMRI data from 35 young, healthy male subjects, we examined how heart rate variability (HRV) covaries with temporal changes in whole-brain functional connectivity with seed regions previously described to mediate effects of vigilance and arousal (amygdala and dorsal anterior cingulate cortex; dACC). We identified a set of regions, including brainstem, thalamus, putamen, and dorsolateral prefrontal cortex, that became more strongly coupled with the dACC and amygdala seeds during states of elevated HRV. Effects differed between high and low frequency components of HRV, suggesting specific contributions of parasympathetic and sympathetic tone on individual connections. Furthermore, dynamics of functional connectivity could be separated from those primarily related to BOLD signal fluctuations. The present results contribute novel information about the neural basis of transient changes of autonomic nervous system states, and suggest physiological and psychological components of the recently observed non-stationarity in resting state functional connectivity.
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DOI：
10.1523/jneurosci.1172-12.2012
发表时间：
2012-08-15
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fan J;Xu P;Van Dam NT;Eilam-Stock T;Gu X;Luo YJ;Hof PR
通讯作者：
Hof PR
影响因子：
14.5
作者：
Critchley, HD;Mathias, CJ;Dolan, RJ
通讯作者：
Dolan, RJ
影响因子：
2.5
作者：
Critchley, HD
通讯作者：
Critchley, HD
影响因子：
3.7
作者：
Gianaros, PJ;Van Der Veen, FM;Jennings, JR
通讯作者：
Jennings, JR
影响因子：
10.8
作者：
BERNARDI, L;SALVUCCI, F;RICCIARDI, L
通讯作者：
RICCIARDI, L