Genistein improves the reproductive performance and bone status of breeder hens during the late egg-laying period.
Genistein improves the reproductive performance and bone status of breeder hens during the late egg-laying period.
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DOI：
10.3382/ps/pez367
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发表时间：
2019-12-01
期刊：
影响因子：
4.4
通讯作者：
Guo YM
中科院分区：
文献类型：
--
作者：
Lv ZP;Yan SJ;Li G;Liu D;Guo YM
染料木黄酮（GEN）是一种大豆异黄酮，在结构和功能上与雌激素相似。研究了日粮基因对种母鸡繁殖性能和骨骼状况的影响。试验选用720只产蛋种鸡，随机分为3组，分别在日粮中添加0、40、400 mg/kg GEN。每个处理组有8个重复，每个重复30只鸡。结果表明，添加GEN能显著提高蛋鸡的产蛋量和蛋壳强度。日粮GEN沉积到蛋黄中，降低了卵泡和蛋黄中的丙二醛。与对照组相比，GEN处理组血清中的卵黄蛋白原（VTG）、孕酮和卵泡刺激素水平升高。此外，GEN处理下调输卵管中胰岛素样生长因子结合蛋白的mRNA表达，而40 mg/kg GEN处理上调雌激素受体α表达。40和400 mg/kg GEN处理后，肝脏中VTG-II的mRNA表达和输卵管中双调蛋白的mRNA表达均上调。在400 mg/kg GEN处理组中，血清中降钙素和碱性磷酸酶水平与对照组相比升高，这与胫骨中钙和磷水平升高一致。添加GEN（400 mg/kg）可提高LBB鸡胫骨强度，但40 mg/kg GEN对产蛋性能的影响更好。综上所述，在蛋鸡产蛋后期添加GEN可提高产蛋量和蛋品质，改善蛋鸡的骨骼状况。
Genistein (GEN), a type of soy isoflavones, is similar to estrogen structurally and functionally. The effects of dietary gen on the reproductive performance and bone status of breeder hens were investigated. A total pf 720 laying broiler breeder (LBB) hens were randomly allocated into 3 groups with supplemental dietary GEN doses (0, 40, 400 mg/kg). Each treatment has 8 replicates of 30 birds. The results indicated that supplemental GEN significantly improved the egg production and eggshell strength of LBB hens. Dietary GEN was deposited into the egg yolk, which decreased malonaldehyde in the follicle and egg yolk. The levels of vitellogenin (VTG), progesterone, and follicle-stimulating hormone in the serum of GEN-treated groups were elevated compared with the control group. Furthermore, GEN treatment downregulated the mRNA expression of insulin-like growth factor binding protein in the fallopian tube, whereas 40 mg/kg GEN treatment upregulated estrogen receptor α expression. Both the mRNA expression of VTG-II in the liver and mRNA expression of amphiregulin in the fallopian tube were upregulated after 40 and 400 mg/kg GEN treatment. In the 400 mg/kg GEN-treated group, the levels of calcitonin and alkaline phosphatase in the serum were increased compared with the control group, which was consistent with the increased levels of calcium and phosphorus in the tibia. Supplemental GEN (400 mg/kg) improved the tibia strength of LBB hens, whereas 40 mg/kg GEN had better effects on laying performance. In summary, dietary GEN could improve the egg production and quality, as well as the bone status of LBB hens during the late egg-laying period.
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影响因子：
6.1
作者：
Ni, Yingdong;Zhu, Qian;Zhao, Ruqian
通讯作者：
Zhao, Ruqian
影响因子：
4.2
作者：
Arjmandi, BH;Alekel, L;Kukreja, SC
通讯作者：
Kukreja, SC
DOI：
10.1024/0300-9831.73.2.120
发表时间：
2003-03-01
影响因子：
2.3
作者：
Cassidy, A
通讯作者：
Cassidy, A
影响因子：
4.4
作者：
Akdemir, F.;Sahin, K.
通讯作者：
Sahin, K.
影响因子：
4.4
作者：
Jiang, Z. Y.;Jiang, S. Q.;Wu, T. X.
通讯作者：
Wu, T. X.