Recurrent Circuitry for Balancing Sleep Need and Sleep.
Recurrent Circuitry for Balancing Sleep Need and Sleep.
复制标题
复发电路平衡睡眠需求和睡眠。
DOI：
10.1016/j.neuron.2017.12.016
复制
发表时间：
2018-01-17
期刊：
影响因子：
16.2
通讯作者：
Miesenböck G
中科院分区：
文献类型：
--
作者：
Donlea JM;Pimentel D;Talbot CB;Kempf A;Omoto JJ;Hartenstein V;Miesenböck G
果蝇背部扇形身体(DFB)中的促进睡眠神经元是睡眠稳态所必需的，但这些细胞如何对机体施加睡眠尚不清楚。我们报道，DFB神经元通过抑制性递质进行交流，其中包括生长抑素-A(ASTA)，中间神经元连接上弓和中央复合体的椭球体。这些“螺旋细胞”表达甘丙肽受体同系物Asta-R1，对视觉输入、门的移动做出反应，并被Asta抑制，这表明DFB神经元通过抑制视觉引导的运动来促进休息。由DFB神经元的合成抑素能传递的增强或减弱以及对螺旋细胞的抑制或光遗传刺激所引起的睡眠变化支持这一观点。螺旋细胞为椭球体的R2神经元提供兴奋，其活动依赖的可塑性向DFB发出睡眠压力上升的信号。通过这个自动调节回路，DFB介导的抑制中断了导致睡眠欠债的过程，允许恢复性睡眠重新平衡账簿。促进睡眠的DFB神经元抑制中枢复合体的螺旋细胞将视觉信号传递给R2环神经元和门运动神经元，产生睡眠需要的神经元和睡眠诱导神经元是经常连接的。一个统一的机制解释了睡眠神经元编码睡眠需要和睡眠诱导神经元的感觉、运动和稳态特征。回路中的一个关键环节对于视觉引导的运动是必要的，但在睡眠中受到抑制。因此，一个统一的机制可以解释睡眠的感觉、运动和体内平衡方面的问题。
Sleep-promoting neurons in the dorsal fan-shaped body (dFB) of Drosophila are integral to sleep homeostasis, but how these cells impose sleep on the organism is unknown. We report that dFB neurons communicate via inhibitory transmitters, including allatostatin-A (AstA), with interneurons connecting the superior arch with the ellipsoid body of the central complex. These “helicon cells” express the galanin receptor homolog AstA-R1, respond to visual input, gate locomotion, and are inhibited by AstA, suggesting that dFB neurons promote rest by suppressing visually guided movement. Sleep changes caused by enhanced or diminished allatostatinergic transmission from dFB neurons and by inhibition or optogenetic stimulation of helicon cells support this notion. Helicon cells provide excitation to R2 neurons of the ellipsoid body, whose activity-dependent plasticity signals rising sleep pressure to the dFB. By virtue of this autoregulatory loop, dFB-mediated inhibition interrupts processes that incur a sleep debt, allowing restorative sleep to rebalance the books. Sleep-promoting dFB neurons inhibit helicon cells of the central complex Helicon cells transmit visual signals to R2 ring neurons and gate locomotion Neurons generating sleep need and sleep-inducing neurons are recurrently connected A unified mechanism accounts for sensory, motor, and homeostatic features of sleep Neurons encoding sleep need and sleep-inducing neurons are recurrently connected. A crucial link in the circuit is necessary for visually guided movements but inhibited during sleep. A unified mechanism can thus account for sensory, motor, and homeostatic aspects of sleep.
登录
查看更多内容
影响因子：
4.5
作者：
Chen J;Reiher W;Hermann-Luibl C;Sellami A;Cognigni P;Kondo S;Helfrich-Förster C;Veenstra JA;Wegener C
通讯作者：
Wegener C
影响因子：
8.8
作者：
Jenett, Arnim;Rubin, Gerald M.;Zugates, Christopher T.
通讯作者：
Zugates, Christopher T.
影响因子：
16.2
作者：
Donlea JM;Pimentel D;Miesenböck G
通讯作者：
Miesenböck G
影响因子：
56.9
作者：
Kim, Sung Soo;Rouault, Herve;Jayaraman, Vivek
通讯作者：
Jayaraman, Vivek
影响因子：
25
作者：
Foltenyi, Krisztina;Greenspan, Ralph J.;Newport, John W.
通讯作者：
Newport, John W.