Variability in DNA Repair Capacity Levels among Molecular Breast Cancer Subtypes: Triple Negative Breast Cancer Shows Lowest Repair.
Variability in DNA Repair Capacity Levels among Molecular Breast Cancer Subtypes: Triple Negative Breast Cancer Shows Lowest Repair.
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分子乳腺癌亚型中DNA修复能力水平的变异性：三重阴性乳腺癌的修复最低。
DOI：
10.3390/ijms18071505
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发表时间：
2017-07-12
影响因子：
5.6
通讯作者：
Suárez E
中科院分区：
文献类型：
--
作者：
Matta J;Ortiz C;Encarnación J;Dutil J;Suárez E
乳腺癌（BC）是一种异质性疾病，许多研究将其分为至少四种分子亚型：Luminal a、Luminal B、her2富集型和basal样（包括三阴性乳腺癌，TNBC）。这些亚型提供了对患者进行分层的信息，以便更好地预测预后和选择治疗方法。由于DNA修复能力（DRC）水平的差异，个体对致癌物的敏感性各不相同。虽然我们之前的病例对照研究确定了低DRC（就NER途径而言）是BC的危险因素，但我们的目标是在分子亚型中研究这种影响。因此，本研究的目的包括调查DRC在分子亚型之间是否存在差异，并测试DRC之间的任何关联。这项研究包括267名新近诊断为BC的妇女（病例）和682名未诊断为BC的妇女（对照组）。我们的研究结果显示DRC在不同的分子亚型中有很大的差异，TNBC病例（n = 47）的DRC最低（p值< 0.05）。几乎80%的BC病例DRC低于中位数（4.3%）。低DRC与TNBC亚型密切相关（OR 7.2; 95% CI 3.3, 15.7）。总之，我们的研究首次报道了分子亚型之间的变异性，并提供了基于DRC水平的TNBC预后不良的假设。
Breast cancer (BC) is a heterogeneous disease which many studies have classified in at least four molecular subtypes: Luminal A, Luminal B, HER2-Enriched, and Basal-like (including triple-negative breast cancer, TNBC). These subtypes provide information to stratify patients for better prognostic predictions and treatment selection. Individuals vary in their sensitivities to carcinogens due to differences in their DNA repair capacity (DRC) levels. Although our previous case-control study established low DRC (in terms of NER pathway) as a BC risk factor, we aim to study this effect among the molecular subtypes. Therefore, the objectives of this study include investigating whether DRC varies among molecular subtypes and testing any association regarding DRC. This study comprised 267 recently diagnosed women with BC (cases) and 682 without BC (controls). Our results show a substantial variability in DRC among the molecular subtypes, with TNBC cases (n = 47) having the lowest DRC (p-value < 0.05). Almost 80 percent of BC cases had a DRC below the median (4.3%). Low DRC was strongly associated with the TNBC subtype (OR 7.2; 95% CI 3.3, 15.7). In conclusion, our study provides the first report on the variability among the molecular subtypes and provides a hypothesis based on DRC levels for the poor prognosis of TNBC.
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DNA修复与女性乳腺癌风险的关联。比较观察性研究。
影响因子：
3.8
作者：
Matta J;Echenique M;Negron E;Morales L;Vargas W;Gaetan FS;Lizardi ER;Torres A;Rosado JO;Bolaños G;Cruz JG;Laboy J;Barnes R;Medina SS;Romero A;Martinez R;Dutil J;Suarez E;Alvarez-Garriga C;Bayona M
通讯作者：
Bayona M
影响因子：
4.6
作者：
Bekele RT;Venkatraman G;Liu RZ;Tang X;Mi S;Benesch MG;Mackey JR;Godbout R;Curtis JM;McMullen TP;Brindley DN
通讯作者：
Brindley DN
影响因子：
6.2
作者：
Ramos, JM;Ruiz, A;Matta, JL
通讯作者：
Matta, JL
影响因子：
3.8
作者：
Gaudet MM;Press MF;Haile RW;Lynch CF;Glaser SL;Schildkraut J;Gammon MD;Douglas Thompson W;Bernstein JL
通讯作者：
Bernstein JL
影响因子：
45.3
作者：
Partridge, Ann H.;Rumble, R. Bryan;Smith, Ian E.
通讯作者：
Smith, Ian E.