Semen parameters in fertile US men: the Study for Future Families.
Semen parameters in fertile US men: the Study for Future Families.
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DOI：
10.1111/j.2047-2927.2013.00125.x
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发表时间：
2013-11
期刊：
影响因子：
4.5
通讯作者：
Study for Future Families Research Group
中科院分区：
文献类型：
--
作者：
Redmon JB;Thomas W;Ma W;Drobnis EZ;Sparks A;Wang C;Brazil C;Overstreet JW;Liu F;Swan SH;Study for Future Families Research Group
建立正常生育男性精液参数参考值对准确评估、咨询和治疗男性因素不育具有重要意义。确定精液质量的时间或地理变异性还需要准确测量特征明确、定义明确的男性人群的精液参数。未来家庭研究（SFF）招募了在加利福尼亚州洛杉矶、明尼苏达州明尼阿波利斯、密苏里州哥伦比亚、纽约州纽约市和爱荷华州爱荷华州市的产前诊所就诊的孕妇的伴侣。采用严格的质量控制和明确的方案，现场采集了763名男性（73%为白色，15%为西班牙裔/拉丁裔，7%为黑人，5%为亚洲人或其他种族）的精液样本。在每个中心测量精液体积（按重量计）、精子浓度（血细胞计数器）和精子活力。在中心实验室测定精子形态（严格和）。平均禁欲时间为3.2天。平均值（中位数;第5 - 95百分位数）值为：精液量，3.9（3.7; 1.5 - 6.8）ml;精子浓度，60（67; 12-192）× 106/ml;精子总数209（240; 32-763）× 106;活动%，51（52; 28-67）%; 14-395）× 106。对于（严格）和标准，精子形态正常值分别为11（10; 3-20）%和57（59; 38-72）%。黑人男性的精液量、精子浓度和活动精子总数显著低于白色和西班牙裔/拉丁裔男性。更快怀孕的男性精液参数略高，但差异很小，没有统计学意义。SFF提供了生活在美国五个不同地理位置的有生育能力的男性的精液参数的可靠估计。有生育能力的男性在传统上用于评估生育能力的所有精液参数中显示出广泛的变化。
Establishing reference norms for semen parameters in fertile men is important for accurate assessment, counseling and treatment of men with male factor infertility. Identifying temporal or geographic variability in semen quality also requires accurate measurement of semen parameters in well-characterized, defined populations of men. The Study for Future Families (SFF) recruited men who were partners of pregnant women attending prenatal clinics in Los Angeles CA, Minneapolis MN, Columbia MO, New York City NY and Iowa City IA. Semen samples were collected on site from 763 men (73% White, 15% Hispanic/Latino, 7% Black and 5% Asian or other ethnic group) using strict quality control and well-defined protocols. Semen volume (by weight), sperm concentration (hemacytometer) and sperm motility were measured at each center. Sperm morphology (both strict and) was determined at a central laboratory. Mean abstinence was 3.2 days. Mean (median; 5th – 95th percentile) values were: semen volume, 3.9 (3.7; 1.5 – 6.8) ml; sperm concentration, 60 (67; 12–192) × 106/ml; total sperm count 209 (240; 32–763) × 106; % motile, 51 (52; 28–67) %; and total motile sperm count, 104 (128; 14–395) × 106, respectively. Values for sperm morphology were 11 (10; 3–20) % and 57 (59; 38–72) % normal forms for (strict) and criteria, respectively. Black men had significantly lower semen volume, sperm concentration and total motile sperm counts than White and Hispanic/Latino men. Semen parameters were marginally higher in men who achieved pregnancy more quickly but differences were small and not statistically significant. The SFF provides robust estimates of semen parameters in fertile men living in five different geographic locations in the US. Fertile men display wide variation in all of the semen parameters traditionally used to assess fertility potential.
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通讯作者：
Study for Future Families Research Group