Semen quality in relation to biomarkers of pesticide exposure.
Semen quality in relation to biomarkers of pesticide exposure.
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DOI：
10.1289/ehp.6417
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发表时间：
2003-09
影响因子：
10.4
通讯作者：
Study for Future Families Research Group
中科院分区：
文献类型：
--
作者：
Swan SH;Kruse RL;Liu F;Barr DB;Drobnis EZ;Redmon JB;Wang C;Brazil C;Overstreet JW;Study for Future Families Research Group
我们之前报道过美国农业地区（密苏里州哥伦比亚）的有生育能力男性的精子浓度和活动性低于美国城市中心（明尼阿波利斯，MN；洛杉矶，CA；纽约）的男性。在目前的研究中，我们提出了一个假设，即目前在中西部农业中使用的农药导致了精液质量的这些差异。我们选择了所有精液参数（浓度、正常形态精子百分比和活动精子百分比）都很低的男性（病例）和所有精液参数都在正常范围内的男性（对照组），分别为密苏里州和明尼苏达州（样本量分别为50和36），并在收集精液时提供的尿液样本中测量了8种常用农药的代谢物。所有农药分析均以中心和病例对照状态为盲法进行。与对照组相比，密苏里州病例的农药代谢物水平升高，除草剂甲草胺和阿特拉津以及杀虫剂二嗪农[2-异丙氧基-4-甲基嘧啶（IMPY）]；对于甲草胺、阿特拉津和IMPY的Wilcoxon秩检验，p分别为0.0007、0.012和0.0004。来自密苏里州的甲草胺或IMPY水平高的男性比低水平的男性更容易出现病例[甲草胺和IMPY的比值比（or）分别为30.0和16.7]，阿特拉津水平高于检测限的男性也是如此（or = 11.3）。在一些分析中，除草剂2,4-d（2,4-二氯苯氧乙酸）和甲草胺也与精液质量差有关，而乙草胺的含量在病例中低于对照组（p = 0.04）。在农业农药水平较低的明尼苏达州，没有发现任何杀虫剂、驱蚊剂避蚊胺（N，N-二乙基-间甲苯酰胺）或马拉硫磷代谢物马拉硫磷二羧酸的显著关联。当前使用的农药与精液质量下降之间的联系表明，我们之前报道过的农业化学品可能导致了密苏里州中部育龄男性精液质量下降。
We previously reported reduced sperm concentration and motility in fertile men in a U.S. agrarian area (Columbia, MO) relative to men from U.S. urban centers (Minneapolis, MN; Los Angeles, CA; New York, NY). In the present study we address the hypothesis that pesticides currently used in agriculture in the Midwest contributed to these differences in semen quality. We selected men in whom all semen parameters (concentration, percentage sperm with normal morphology, and percentage motile sperm) were low (cases) and men in whom all semen parameters were within normal limits (controls) within Missouri and Minnesota (sample sizes of 50 and 36, respectively) and measured metabolites of eight current-use pesticides in urine samples provided at the time of semen collection. All pesticide analyses were conducted blind with respect to center and case-control status. Pesticide metabolite levels were elevated in Missouri cases, compared with controls, for the herbicides alachlor and atrazine and for the insecticide diazinon [2-isopropoxy-4-methyl-pyrimidinol (IMPY)]; for Wilcoxon rank test, p = 0.0007, 0.012, and 0.0004 for alachlor, atrazine, and IMPY, respectively. Men from Missouri with high levels of alachlor or IMPY were significantly more likely to be cases than were men with low levels [odds ratios (ORs) = 30.0 and 16.7 for alachlor and IMPY, respectively], as were men with atrazine levels higher than the limit of detection (OR = 11.3). The herbicides 2,4-D (2,4-dichlorophenoxyacetic acid) and metolachlor were also associated with poor semen quality in some analyses, whereas acetochlor levels were lower in cases than in controls (p = 0.04). No significant associations were seen for any pesticides within Minnesota, where levels of agricultural pesticides were low, or for the insect repellent DEET (N,N-diethyl-m-toluamide) or the malathion metabolite malathion dicarboxylic acid. These associations between current-use pesticides and reduced semen quality suggest that agricultural chemicals may have contributed to the reduction in semen quality in fertile men from mid-Missouri we reported previously.
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影响因子：
105.7
作者：
Ekbom, A;Hsieh, CC;Trichopoulos, D
通讯作者：
Trichopoulos, D
影响因子：
3.3
作者：
KNIEWALD, J;OSREDECKI, V;KNIEWALD, Z
通讯作者：
KNIEWALD, Z
影响因子：
6.1
作者：
Konda, LN;Pásztor, Z
通讯作者：
Pásztor, Z
影响因子：
6.1
作者：
Jorgensen, N;Andersen, AG;Skakkebæk, NE
通讯作者：
Skakkebæk, NE
影响因子：
7.4
作者：
Beeson, MD;Driskell, WJ;Barr, DB
通讯作者：
Barr, DB