Human longevity is associated with regular sleep patterns, maintenance of slow wave sleep, and favorable lipid profile.
Human longevity is associated with regular sleep patterns, maintenance of slow wave sleep, and favorable lipid profile.
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DOI：
10.3389/fnagi.2014.00134
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发表时间：
2014
影响因子：
4.8
通讯作者：
Tufik S
中科院分区：
文献类型：
--
作者：
Mazzotti DR;Guindalini C;Moraes WA;Andersen ML;Cendoroglo MS;Ramos LR;Tufik S
一些人能够成功地达到很高的年龄，反映出对年龄相关影响的更高适应能力。睡眠是受衰老影响最深的过程之一；然而，到目前为止，很少有研究评估长寿人士(85岁以上)的睡眠。本研究的目的是描述老年人(N=10，年龄85~105岁)的睡眠模式和生化特征，并将其与年轻人(N=15，年龄20~30岁)和老年人(N=13，年龄60~70岁)进行比较。所有受试者都接受了通宵多导睡眠监测、1周的动态记录和外周血液采集。同时进行睡眠脑电频谱分析。与老年人相比，年龄最大的老年人表现出较低的睡眠效率和REM睡眠，而N3期百分比和增量功率在各组中相似。年龄最大的老年人严格保持有规律的睡眠-醒来时间表，也比老年人表现出更高的高密度脂蛋白-胆固醇和更低的甘油三酯水平。目前的研究揭示了关于年龄最大的老年组中特定睡眠模式和慢波睡眠维持的新数据。结合有利的脂类分布，这些结果有助于证明睡眠和脂代谢调节在维持人类寿命方面的重要性。
Some individuals are able to successfully reach very old ages, reflecting higher adaptation against age-associated effects. Sleep is one of the processes deeply affected by aging; however few studies evaluating sleep in long-lived individuals (aged over 85) have been reported to date. The aim of this study was to characterize the sleep patterns and biochemical profile of oldest old individuals (N = 10, age 85–105 years old) and compare them to young adults (N = 15, age 20–30 years old) and older adults (N = 13, age 60–70 years old). All subjects underwent full-night polysomnography, 1-week of actigraphic recording and peripheral blood collection. Sleep electroencephalogram spectral analysis was also performed. The oldest old individuals showed lower sleep efficiency and REM sleep when compared to the older adults, while stage N3 percentage and delta power were similar across the groups. Oldest old individuals maintained strictly regular sleep-wake schedules and also presented higher HDL-cholesterol and lower triglyceride levels than older adults. The present study revealed novel data regarding specific sleep patterns and maintenance of slow wave sleep in the oldest old group. Taken together with the favorable lipid profile, these results contribute with evidence to the importance of sleep and lipid metabolism regulation in the maintenance of longevity in humans.
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影响因子：
3.2
作者：
Edwards BA;O'Driscoll DM;Ali A;Jordan AS;Trinder J;Malhotra A
通讯作者：
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作者：
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作者：
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通讯作者：
Tufik, S.
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作者：
Landolt, HP;Borbély, AA
通讯作者：
Borbély, AA