Structural disconnection of the posterior medial frontal cortex reduces speech error monitoring.
Structural disconnection of the posterior medial frontal cortex reduces speech error monitoring.
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DOI：
10.1016/j.nicl.2021.102934
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Turkeltaub PE
中科院分区：
文献类型：
--
作者：
McCall JD;Vivian Dickens J;Mandal AS;DeMarco AT;Fama ME;Lacey EH;Kelkar A;Medaglia JD;Turkeltaub PE
结构性断开与减少的语音错误监测有关。pMFC与语音处理区域的断开减少了语音错误监测。pMFC与执行区的断开减少了语音错误监测。任何任务的最佳性能都依赖于检测和纠正错误的能力。前扣带皮层和更广泛的后内侧额叶皮层（pMFC）在错误处理过程中是活跃的。然而，目前还不清楚pMFC的损坏是否会损害错误监测。我们假设，成功的错误监控关键依赖于pMFC和更广泛的皮质网络参与执行功能和任务被监测之间的连接。我们在中风后失语症患者的言语错误监测中验证了这一假设。在51名慢性左半球卒中的成年人和37名年龄匹配的对照参与者中收集了弥散加权图像。全脑连接组的推导使用约束球面解卷积和解剖约束概率纤维束成像。支持向量回归确定白色物质连接，其中失去了完整性中风幸存者减少错误检测在对抗命名。与双侧pMFC的受损连接与减少错误监测有关，包括许多与言语产生和执行功能相关的区域的连接。我们的结论是连接到pMFC支持错误监控。言语产生中的错误监测由pMFC与言语产生、理解和执行功能中所涉及的区域之间的结构连接支持。pMFC和其他任务相关处理器之间的交互对于其他任务上下文中的错误监控可能同样至关重要。
Structural disconnections relate to reduced speech error monitoring. Disconnection of pMFC from speech processing regions reduces speech error monitoring. Disconnection of pMFC from executive regions reduces speech error monitoring. Optimal performance in any task relies on the ability to detect and correct errors. The anterior cingulate cortex and the broader posterior medial frontal cortex (pMFC) are active during error processing. However, it is unclear whether damage to the pMFC impairs error monitoring. We hypothesized that successful error monitoring critically relies on connections between the pMFC and broader cortical networks involved in executive functions and the task being monitored. We tested this hypothesis in the context of speech error monitoring in people with post-stroke aphasia. Diffusion weighted images were collected in 51 adults with chronic left-hemisphere stroke and 37 age-matched control participants. Whole-brain connectomes were derived using constrained spherical deconvolution and anatomically-constrained probabilistic tractography. Support vector regressions identified white matter connections in which lost integrity in stroke survivors related to reduced error detection during confrontation naming. Lesioned connections to the bilateral pMFC were related to reduce error monitoring, including many connections to regions associated with speech production and executive function. We conclude that connections to the pMFC support error monitoring. Error monitoring in speech production is supported by the structural connectivity between the pMFC and regions involved in speech production, comprehension, and executive function. Interactions between pMFC and other task-relevant processors may similarly be critical for error monitoring in other task contexts.
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