Respiratory mechanics and gas exchange in an ovine model of congenital heart disease with increased pulmonary blood flow and pressure.
Respiratory mechanics and gas exchange in an ovine model of congenital heart disease with increased pulmonary blood flow and pressure.
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DOI：
10.3389/fphys.2023.1188824
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发表时间：
2023
影响因子：
4
通讯作者：
Datar SA
中科院分区：
文献类型：
--
作者：
Soares JHN;Raff GW;Fineman JR;Datar SA
在先天性心脏病（CHD）模型中，我们评估了肺血流量和压力的慢性增加是否与呼吸力学和气体交换的改变有关。在6只分流、7只SHAM和7只对照年龄匹配的羔羊中评价呼吸力学和气体交换。麻醉羔羊，机械通气15分钟，潮气量为10 mL/kg，呼气末正压为5 cmH 2 O，吸入氧分数为0.21。评价呼吸系统、肺和胸壁顺应性（分别为Crs、CL和Ccw）和阻力（分别为Rrs、RL和Rcw）以及弹性压力-容积曲线（%E2）的轮廓。收集动脉血气和容积二氧化碳监测变量。对于正态分布数据，通过单因素ANOVA，然后进行Tukey-Kramer检验，对于非正态分布数据，通过Kruskal-Wallis检验，然后进行Steel-Dwass检验进行组间比较。分流组的平均Crs和CL分别比对照组低30%和58%，比假手术组低56%和68%。与对照组和SHAM相比，分流羔羊的Ccw分别高52%和47%，Rcw分别低53%和40%。未发现组间%E2存在差异。对照组和假手术组羔羊的呼吸力学无明显差异。在分流羔羊，Rcw，Crs和CL降低，Ccw增加时，与对照组和SHAM羔羊。与对照组和假手术组相比，分流组羔羊的肺气体交换似乎没有受损。
In a model of congenital heart disease (CHD), we evaluated if chronically increased pulmonary blood flow and pressure were associated with altered respiratory mechanics and gas exchange. Respiratory mechanics and gas exchange were evaluated in 6 shunt, 7 SHAM, and 7 control age-matched lambs. Lambs were anesthetized and mechanically ventilated for 15 min with tidal volume of 10 mL/kg, positive end-expiratory pressure of 5 cmH2O, and inspired oxygen fraction of 0.21. Respiratory system, lung and chest wall compliances (Crs, CL and Ccw, respectively) and resistances (Rrs, RL and Rcw, respectively), and the profile of the elastic pressure-volume curve (%E2) were evaluated. Arterial blood gases and volumetric capnography variables were collected. Comparisons between groups were performed by one-way ANOVA followed by Tukey-Kramer test for normally distributed data and with Kruskal–Wallis test followed by Steel-Dwass test for non-normally distributed data. Average Crs and CL in shunt lambs were 30% and 58% lower than in control, and 56% and 68% lower than in SHAM lambs, respectively. Ccw was 52% and 47% higher and Rcw was 53% and 40% lower in shunt lambs compared to controls and SHAMs, respectively. No difference in %E2 was identified between groups. No difference in respiratory mechanics was observed between control and SHAM lambs. In shunt lambs, Rcw, Crs and CL were decreased and Ccw was increased when compared to control and SHAM lambs. Pulmonary gas exchange did not seem to be impaired in shunt lambs when compared to controls and SHAMs.
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影响因子：
3.5
作者：
Abassi, Hamouda;Gavotto, Arthur;Amedro, Pascal
通讯作者：
Amedro, Pascal
影响因子：
5.1
作者：
BANCALARI, E;JESSE, MJ;GARCIA, O
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GARCIA, O
影响因子：
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作者：
HORDOF, AJ;MELLINS, RB;STEEG, CN
通讯作者：
STEEG, CN
影响因子：
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作者：
HOWLETT, G
通讯作者：
HOWLETT, G
影响因子：
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作者：
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通讯作者：
Demiroluk, S