Biohybrid Micro- and Nanorobots for Intelligent Drug Delivery.

Biohybrid Micro- and Nanorobots for Intelligent Drug Delivery.
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DOI:
10.34133/2022/9824057
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发表时间:
2022
期刊:
Cyborg and bionic systems (Washington, D.C.)
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其他
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生物混合微型和纳米机器人是由生物组件和人造组件集成的微型机器。它们可以具有机载驱动、传感、控制和执行多种医疗任务的优势,例如靶向药物输送、单细胞操纵和细胞显微手术。这篇综述论文概述了用于智能药物输送应用的生物混合微型和纳米机器人。首先,详细回顾了包含不同生物组件的各种生物混合微型和纳米机器人。随后,介绍了生物混合微型和纳米机器人在主动药物输送方面的应用,以展示这种生物混合微型和纳米机器人如何在医学和保健领域得到利用。最后,讨论了需要克服的关键挑战,为生物混合微纳米机器人的临床转化和应用铺平道路。
Biohybrid micro- and nanorobots are integrated tiny machines from biological components and artificial components. They can possess the advantages of onboard actuation, sensing, control, and implementation of multiple medical tasks such as targeted drug delivery, single-cell manipulation, and cell microsurgery. This review paper is to give an overview of biohybrid micro- and nanorobots for smart drug delivery applications. First, a wide range of biohybrid micro- and nanorobots comprising different biological components are reviewed in detail. Subsequently, the applications of biohybrid micro- and nanorobots for active drug delivery are introduced to demonstrate how such biohybrid micro- and nanorobots are being exploited in the field of medicine and healthcare. Lastly, key challenges to be overcome are discussed to pave the way for the clinical translation and application of the biohybrid micro- and nanorobots.
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