Eph and ephrin signaling in the formation of topographic maps.
Eph and ephrin signaling in the formation of topographic maps.
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DOI：
10.1016/j.semcdb.2011.10.026
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发表时间：
2012-02
影响因子：
7.3
通讯作者：
Feldheim, David A.
中科院分区：
文献类型：
--
作者：
Triplett, Jason W.;Feldheim, David A.
视网膜与其中脑靶点（上级丘（SC））之间的轴突连接被地形映射，使得当终止于SC时维持视网膜中细胞体的空间关系。地形图开发使用笛卡尔映射系统，使得视网膜的每个轴被独立地映射。沿着鼻-颞映射轴，EphAs和肝配蛋白-As是地形映射所需的分级分子线索，而背-腹轴部分地通过EphB和肝配蛋白-Bs映射。因为Ephs和ephrin都是细胞表面分子，它们可以在正向和反向方向上发出信号。Eph/ephrin信号传导导致细胞骨架动力学的变化，其导致肌动蛋白解聚和内吞作用，通过吸引和排斥引导轴突。
The axonal connections between the retina and its midbrain target, the superior colliculus (SC), is mapped topographically, such that the spatial relationships of cell bodies in the retina are maintained when terminating in the SC. Topographic map development uses a Cartesian mapping system such that each axis of the retina is mapped independently. Along the nasal-temporal mapping axis, EphAs and ephrin-As, are graded molecular cues required for topographic mapping while the dorsal-ventral axis is mapped in part via EphB and ephrin-Bs. Because both Ephs and ephrins are cell surface molecules they can signal in the forward and reverse directions. Eph/ephrin signaling leads to changes in cytoskeletal dynamics that lead to actin depolymerization and endocytosis guiding an axons via attraction and repulsion.
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影响因子：
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