Organization of the Human Frontal Pole Revealed by Large-Scale DTI-Based Connectivity: Implications for Control of Behavior.
Organization of the Human Frontal Pole Revealed by Large-Scale DTI-Based Connectivity: Implications for Control of Behavior.
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DOI：
10.1371/journal.pone.0124797
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Banich MT
中科院分区：
文献类型：
--
作者：
Orr JM;Smolker HR;Banich MT
目前研究的目的是检查人类额叶的解剖连接模式，以便为额叶功能的理论提供信息，这可能是人类大脑中最不了解的区域之一。我们并没有简单地将额极划分为不同的子区域，而是专注于检查与额极在解剖学和功能上相连的大脑区域。虽然目前的研究结果为以前的工作提供了支持，表明额极与高阶感觉联合皮层相连，但我们发现了新的证据，表明人类的额极与后部视觉皮层相连。此外，我们提出了一个功能框架，将这些解剖连接与现有的认知理论的功能组织的额极。除了先前讨论的内外侧的区别，我们提出了一个背腹梯度的基础上的信息额极用于指导行为。我们认为，背侧区域与处理目标和行动计划的其他前额叶区域相连，内侧区域与监控行动结果和激励行为的其他大脑区域相连，腹侧区域与处理有关刺激，价值和情感的信息的区域相连。通过整合这些不同层次的信息，额极可以有效地引导目标导向行为。
The goal of the current study was to examine the pattern of anatomical connectivity of the human frontal pole so as to inform theories of function of the frontal pole, perhaps one of the least understood region of the human brain. Rather than simply parcellating the frontal pole into subregions, we focused on examining the brain regions to which the frontal pole is anatomically and functionally connected. While the current findings provided support for previous work suggesting the frontal pole is connected to higher-order sensory association cortex, we found novel evidence suggesting that the frontal pole in humans is connected to posterior visual cortex. Furthermore, we propose a functional framework that incorporates these anatomical connections with existing cognitive theories of the functional organization of the frontal pole. In addition to a previously discussed medial-lateral distinction, we propose a dorsal-ventral gradient based on the information the frontal pole uses to guide behavior. We propose that dorsal regions are connected to other prefrontal regions that process goals and action plans, medial regions are connected to other brain regions that monitor action outcomes and motivate behaviors, and ventral regions connect to regions that process information about stimuli, values, and emotion. By incorporating information across these different levels of information, the frontal pole can effectively guide goal-directed behavior.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
DOI：
10.1523/jneurosci.2180-11.2011
发表时间：
2011-08-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Kalisch, Raffael
影响因子：
3.3
作者：
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通讯作者：
Behrens, Timothy E. J.
影响因子：
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作者：
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