Ensheathing cells utilize dynamic tiling of neuronal somas in development and injury as early as neuronal differentiation.
Ensheathing cells utilize dynamic tiling of neuronal somas in development and injury as early as neuronal differentiation.
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DOI：
10.1186/s13064-018-0115-8
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发表时间：
2018-08-18
影响因子：
3.6
通讯作者：
Smith CJ
中科院分区：
文献类型：
--
作者：
Nichols EL;Green LA;Smith CJ
神经回路中特定成分的神经胶质细胞包膜是神经系统功能所必需的。尽管已经对分化神经元轴突的包膜进行了研究，但神经元胞体的包膜作用，特别是在神经元伸展过程和祖细胞群体扩大的早期发育过程中，仍然很大程度上是未知的。为了解决这个问题，我们在斑马鱼背根神经节(DRG)的初始形成过程中使用了时间推移成像。我们的结果表明，DRG神经元在其整个生命周期中都被祖细胞群体所覆盖。这些包膜细胞在发育过程中动态重塑，以确保轴突可以从神经细胞胞体延伸到中枢神经系统，并向外延伸到皮肤。作为一个群体，套鞘细胞将每个DRG神经元压平，以确保神经元被紧密包裹。在发育和实验性细胞消融范例中，DRG神经元的椭圆形在部分去鞘过程中动态变化。在较长时间的脱鞘过程中，观察到神经元胞体的移位。我们进一步表明，这些鞘细胞与神经元的密切关系导致了对神经元远端轴突损伤的即时和精心设计的反应。我们认为，鞘细胞在发育过程中通过其重塑活动动态地影响背根神经节中神经元的形状和位置，并准备好动态地对神经元的损伤做出反应。本文的在线版本(10.1186/s13064-0180115-8)包含补充材料，可供授权用户使用。
Glial cell ensheathment of specific components of neuronal circuits is essential for nervous system function. Although ensheathment of axonal segments of differentiated neurons has been investigated, ensheathment of neuronal cell somas, especially during early development when neurons are extending processes and progenitor populations are expanding, is still largely unknown. To address this, we used time-lapse imaging in zebrafish during the initial formation of the dorsal root ganglia (DRG). Our results show that DRG neurons are ensheathed throughout their entire lifespan by a progenitor population. These ensheathing cells dynamically remodel during development to ensure axons can extend away from the neuronal cell soma into the CNS and out to the skin. As a population, ensheathing cells tile each DRG neuron to ensure neurons are tightly encased. In development and in experimental cell ablation paradigms, the oval shape of DRG neurons dynamically changes during partial unensheathment. During longer extended unensheathment neuronal soma shifting is observed. We further show the intimate relationship of these ensheathing cells with the neurons leads to immediate and choreographed responses to distal axonal damage to the neuron. We propose that the ensheathing cells dynamically contribute to the shape and position of neurons in the DRG by their remodeling activity during development and are primed to dynamically respond to injury of the neuron. The online version of this article (10.1186/s13064-018-0115-8) contains supplementary material, which is available to authorized users.
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影响因子：
6.2
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神经元活动会影响体内髓鞘形成的轴突选择。
影响因子：
25
作者：
Hines, Jacob H.;Ravanelli, Andrew M.;Schwindt, Rani;Scott, Ethan K.;Appel, Bruce
通讯作者：
Appel, Bruce