A Miniature Multilevel Structures for Lossless Ion Manipulations Ion Mobility Spectrometer with Wide Mobility Range Separation Capabilities.
A Miniature Multilevel Structures for Lossless Ion Manipulations Ion Mobility Spectrometer with Wide Mobility Range Separation Capabilities.
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DOI：
10.1021/acs.analchem.1c04700
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发表时间：
2022-02-01
影响因子：
7.4
通讯作者：
Ibrahim, Yehia M.
中科院分区：
文献类型：
--
作者：
Hollerbach, Adam L.;Norheim, Randolph, V;Kwantwi-Barima, Pearl;Smith, Richard D.;Ibrahim, Yehia M.
采用无损离子操纵结构的离子迁移谱法（SLIM-IMS）是一种有吸引力的气相分离技术，这是由于其能够在小占地面积中实现前所未有的有效离子路径长度（>1 km）和IMS分辨能力。其中离子在垂直堆叠的SLIM电极表面之间转移的多级SLIM技术的出现随后允许实现超长的单程路径长度（>40 m），使得能够在单个实验中在整个迁移率范围内执行100分辨率IMS测量。在这里，我们报告的1米的路径长度的微型SLIM模块（miniSLIM）的基础上多级SLIM技术的发展。利用离子轨道模拟优化了SLIM板间距和SLIM板厚度，提出了一种利用非对称行波（TW）实现SLIM能级间离子高效传输的新方法。我们实验表征的miniSLIM IMS-MS相对于漂移管IMS-MS使用安捷伦调谐混合物阳离子和四烷基铵阳离子的性能。miniSLIM的分辨率高达131（CCS/ΔCCS），比78 cm光程长的漂移管IMS高约1.5倍。此外，整个离子迁移率范围在一次分离中成功传输。我们还展示了miniSLIM作为独立IMS系统的性能（即，没有MS），其显示所有AgTM阳离子之间的基线分离和标准肽混合物的不同电荷状态之间的明显区别。总体而言，miniSLIM为具有相似路径长度的高性能IMS仪器提供了一种紧凑的替代方案。
Ion mobility spectrometry employing structures for lossless ion manipulations (SLIM-IMS) is an attractive gas-phase separation technique due to its ability to achieve unprecedented effective ion path lengths (>1 km) and IMS resolving powers in a small footprint. The emergence of multilevel SLIM technology, where ions are transferred between vertically stacked SLIM electrode surfaces, has subsequently allowed for ultralong single pass path lengths (>40 m) to be achieved, enabling ultrahigh resolution IMS measurements to be performed over the entire mobility range in a single experiment. Here we report on the development of a 1-meter path length miniature SLIM module (miniSLIM) based on multilevel SLIM technology. Ion trajectory simulations were used to optimize SLIM board spacings and SLIM board thicknesses, and a new method of efficiently transferring ions between SLIM levels using asymmetric traveling waves (TWs) was demonstrated. We experimentally characterized the performance of the miniSLIM IMS-MS relative to a drift tube IMS-MS using Agilent tuning mixture cations and tetraalkylammonium cations. The miniSLIM achieved a resolving power of up to 131 (CCS/ΔCCS), which is ~1.5x higher than achievable with a 78-cm path length drift tube IMS. Additionally, the entire ion mobility range was successfully transmitted in a single separation. We also demonstrated the miniSLIM’s performance as a standalone IMS system (i.e., without MS), which showed baseline separation between all AgTM cations and a clear differentiation between different charge states of a standard peptide mixture. Overall the miniSLIM provides a compact alternative to high performance IMS instruments possessing similar path lengths.
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DOI：
10.1039/c7an00031f
发表时间：
2017-03-27
期刊：
The Analyst
影响因子：
--
作者：
Ibrahim YM;Hamid AM;Deng L;Garimella SV;Webb IK;Baker ES;Smith RD
通讯作者：
Smith RD
影响因子：
7.4
作者：
Campuzano, Iain;Bush, Matthew F.;Kim, Hugh I.
通讯作者：
Kim, Hugh I.
影响因子：
7.4
作者：
Kirk, Ansgar T.;Grube, Denise;Zimmermann, Stefan
通讯作者：
Zimmermann, Stefan
影响因子：
7.4
作者：
Stow SM;Causon TJ;Zheng X;Kurulugama RT;Mairinger T;May JC;Rennie EE;Baker ES;Smith RD;McLean JA;Hann S;Fjeldsted JC
通讯作者：
Fjeldsted JC
影响因子：
7.4
作者：
Hamid, Ahmed M.;Ibrahim, Yehia M.;Smith, Richard D.
通讯作者：
Smith, Richard D.