The Changing Epidemiology of Autism Spectrum Disorders.
The Changing Epidemiology of Autism Spectrum Disorders.
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DOI：
10.1146/annurev-publhealth-031816-044318
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发表时间：
2017-03-20
影响因子：
20.8
通讯作者：
Newschaffer C
中科院分区：
文献类型：
--
作者：
Lyall K;Croen L;Daniels J;Fallin MD;Ladd-Acosta C;Lee BK;Park BY;Snyder NW;Schendel D;Volk H;Windham GC;Newschaffer C
自闭症谱系障碍(ASD)是一种复杂的神经发育状况，具有终生影响。遗传和环境因素对ASD的病因有贡献，但至今仍不完全清楚。在过去的十年中，ASD流行病学取得了重大进展。据估计，目前发达国家的患病率至少为1.5%，最近的增长主要是在那些没有并发智力残疾的人中。遗传学研究已经确定了一些罕见的从头突变，并在多基因风险、表观遗传学、多基因风险和基因x环境(GxE)相互作用领域获得了立足点。针对非遗传因素的流行病学调查已确定高龄父母和早产是ASD的危险因素，产前暴露于空气污染和孕期间隔短是潜在的危险因素，并建议进一步探讨某些产前营养、代谢状况和暴露于干扰内分泌的化学物质。讨论了ASD流行病学的未来挑战和目标。
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with lifelong impacts. Genetic and environmental factors contribute to ASD etiology, which remains incompletely understood. Significant advances in ASD epidemiology have been seen in the past decade. Current prevalence is estimated to be at least 1.5% in developed countries, with recent increases primarily among those without comorbid intellectual disability. Genetic studies have identified a number of rare de novo mutations, and gained footing in the areas of polygenic risk, epigenetics, polygenic risk, and gene x environment (GxE) interaction. Epidemiologic investigations focused on non-genetic factors have established advanced parental age and preterm birth as ASD risk factors, indicated that prenatal exposure to air pollution and short inter-pregnancy interval are potential risk factors, and suggest that further exploration of certain prenatal nutrients, metabolic conditions, and exposure to endocrine-disrupting chemicals is warranted. Future challenges and goals for ASD epidemiology are discussed.
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影响因子：
10.4
作者：
Braun JM;Kalkbrenner AE;Just AC;Yolton K;Calafat AM;Sjödin A;Hauser R;Webster GM;Chen A;Lanphear BP
通讯作者：
Lanphear BP
影响因子：
3.9
作者：
Braun, Joseph M.;Froehlich, Tanya;Kalkbrenner, Amy;Pfeiffer, Christine M.;Fazili, Zia;Yolton, Kimberly;Lanphear, Bruce P.
通讯作者：
Lanphear, Bruce P.
影响因子：
5.3
作者：
Bercum, Florencia M.;Rodgers, Krista M.;Barth, Daniel S.
通讯作者：
Barth, Daniel S.
影响因子：
6.4
作者：
Atladottir, Hjordis O.;Gyllenberg, David;Parner, Erik T.
通讯作者：
Parner, Erik T.
影响因子：
6.9
作者：
Baxter, A. J.;Brugha, T. S.;Scott, J. G.
通讯作者：
Scott, J. G.