Brief report: are autistic-behaviors in children related to prenatal vitamin use and maternal whole blood folate concentrations?
Brief report: are autistic-behaviors in children related to prenatal vitamin use and maternal whole blood folate concentrations?
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DOI：
10.1007/s10803-014-2114-x
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发表时间：
2014-10
影响因子：
3.9
通讯作者：
Lanphear, Bruce P.
中科院分区：
文献类型：
--
作者：
Braun, Joseph M.;Froehlich, Tanya;Kalkbrenner, Amy;Pfeiffer, Christine M.;Fazili, Zia;Yolton, Kimberly;Lanphear, Bruce P.
产前使用多种维生素/叶酸补充剂可能会降低自闭症谱系障碍的风险。我们调查了209对母亲-儿童的前瞻性队列中，妊娠中期产前维生素使用和母亲全血叶酸（WBF）浓度是否与4-5岁时的社会反应量表（SRS）评分相关。在混杂因素调整后，每周/每天服用产前维生素的妇女（n=179）所生的儿童临床SRS评分升高的几率（比值比：0.26; 95%置信区间[CI]：0.08，0.89）低于很少/从不服用维生素的妇女（n=30）。WBF浓度与SRS评分无关。WBF和自闭症行为之间缺乏相关性可能是由于生物标志物测量相对于大脑发育的关键时期的时间，混淆或其他修改因素。
Prenatal multivitamin/folic acid supplement use may reduce the risk of autism spectrum disorders. We investigated whether 2nd trimester prenatal vitamin use and maternal whole blood folate (WBF) concentrations were associated with Social Responsiveness Scale (SRS) scores at 4-5 years of age in a prospective cohort of 209 mother-child pairs. After confounder adjustment, children born to women taking prenatal vitamins weekly/daily (n=179) had lower odds of clinically elevated SRS scores (odds ratio:0.26; 95% confidence interval [CI]:0.08, 0.89) than those who rarely/never took them (n=30). WBF concentrations were not associated with SRS scores. The lack of association between WBF and autistic-behaviors may be due to the timing of biomarker measures relative to critical periods of brain development, confounding, or other modifying factors.
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DOI：
10.1097/ede.0b013e31821d0e30
发表时间：
2011-07
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Schmidt RJ;Hansen RL;Hartiala J;Allayee H;Schmidt LC;Tancredi DJ;Tassone F;Hertz-Picciotto I
通讯作者：
Hertz-Picciotto I
影响因子：
5.4
作者：
Shiraishi M;Haruna M;Matsuzaki M;Murayama R;Sasaki S;Murashima S
通讯作者：
Murashima S
影响因子：
158.5
作者：
Rothenberg, SP;da Costa, MP;Quadros, EV
通讯作者：
Quadros, EV
影响因子：
5.2
作者：
Roth, Christine;Bjorke-Monsen, Anne L.;Magnus, Per
通讯作者：
Magnus, Per
影响因子：
8
作者：
Tamura, T;Goldenberg, RL;Nelson, KG
通讯作者：
Nelson, KG