What is the efficacy of aerobic exercise versus strength training in the treatment of migraine? A systematic review and network meta-analysis of clinical trials.
What is the efficacy of aerobic exercise versus strength training in the treatment of migraine? A systematic review and network meta-analysis of clinical trials.
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DOI：
10.1186/s10194-022-01503-y
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发表时间：
2022-10-13
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不同运动方案的多项临床试验已经证明了对偏头痛的治疗效果。然而，不同运动干预措施之间的疗效没有正面比较。对所有临床试验进行了系统回顾和网络荟萃分析，确定了运动干预在减少每月偏头痛发生频率方面的效果。医学期刊搜索引擎包括Web of Science、PubMed和Scope us，涵盖了截至2022年7月30日的所有往年。包括有氧训练和力量/耐力训练方案。活动组和对照组每月偏头痛频率从基线到干预结束的平均差值(MD，95%可信区间)被用作结果衡量标准。通过进行随机效应模型网络荟萃分析，将直接和间接比较的疗效证据结合起来。比较了中等强度有氧运动、大强度有氧运动和力量/耐力训练三种运动方案的效果。将偏头痛药物(托吡酯、阿米替林)与运动的疗效进行比较的研究包括在内。此外，使用Cochrane偏差风险版本2(RoB2)对所有纳入研究中的偏差风险进行评估。已发表的临床试验有21项，共涉及1195名偏头痛患者，平均年龄为35岁，男女比例为6.7。27例为配对对照，8例为间接对照。干预顺序为：力量训练(MD = -3.55[− 6.15， − 0.95])、大强度有氧运动(-3.13[-5.28，-0.97])、中等强度有氧运动(-2.18[-3.25，-1.11])、托吡酯(-0.98[-4.16，2.20])、安慰剂、阿米替林(3.82[− 1.03，8.68])。RoB2评估显示，在纳入的研究中，85%的研究显示偏倚风险较低，而15%的研究在意向治疗分析中显示偏向风险较高。产生偏差的高风险来源包括随机化过程和丢失结果数据的处理。力量训练训练方案在减轻偏头痛负担方面显示出最高的效果，其次是高强度有氧运动。网上版载有补充材料，可在10.1186/s10194-022-01503-y查阅。
Multiple clinical trials with different exercise protocols have demonstrated efficacy in the management of migraine. However, there is no head-to-head comparison of efficacy between the different exercise interventions. A systematic review and network meta-analysis was performed involving all clinical trials which determined the efficacy of exercise interventions in reducing the frequency of monthly migraine. Medical journal search engines included Web of Science, PubMed, and Scopus spanning all previous years up to July 30, 2022. Both aerobic and strength/resistance training protocols were included. The mean difference (MD, 95% confidence interval) in monthly migraine frequency from baseline to end-of-intervention between the active and control arms was used as an outcome measure. Efficacy evidence from direct and indirect comparisons was combined by conducting a random effects model network meta-analysis. The efficacy of the three exercise protocols was compared, i.e., moderate-intensity aerobic exercise, high-intensity aerobic exercise, and strength/resistance training. Studies that compared the efficacy of migraine medications (topiramate, amitriptyline) to exercise were included. Additionally, the risk of bias in all included studies was assessed by using the Cochrane Risk of Bias version 2 (RoB2). There were 21 published clinical trials that involved a total of 1195 migraine patients with a mean age of 35 years and a female-to-male ratio of 6.7. There were 27 pairwise comparisons and 8 indirect comparisons. The rank of the interventions was as follows: strength training (MD = -3.55 [− 6.15, − 0.95]), high-intensity aerobic exercise (-3.13 [-5.28, -0.97]), moderate-intensity aerobic exercise (-2.18 [-3.25, -1.11]), topiramate (-0.98 [-4.16, 2.20]), placebo, amitriptyline (3.82 [− 1.03, 8.68]). The RoB2 assessment showed that 85% of the included studies demonstrated low risk of bias, while 15% indicated high risk of bias for intention-to-treat analysis. Sources of high risk of bias include randomization process and handling of missing outcome data. Strength training exercise regimens demonstrated the highest efficacy in reducing migraine burden, followed by high-intensity aerobic exercise. The online version contains supplementary material available at 10.1186/s10194-022-01503-y.
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DOI：
10.1093/brain/awac260
发表时间：
2022-08-27
期刊：
Brain : a journal of neurology
影响因子：
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作者：
通讯作者：
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影响因子：
1.5
作者：
Aslani, Payam Sari;Hassanpour, Maryam;Parnow, Abdolhossein
通讯作者：
Parnow, Abdolhossein
影响因子：
2.5
作者：
Darabaneanu, S.;Overath, C. H.;Weisser, B.
通讯作者：
Weisser, B.
影响因子：
0.9
作者：
Butt, Maryum Naseer;Maryum, Misbah;Awan, Liaqat
通讯作者：
Awan, Liaqat
DOI：
10.1249/00005768-198205000-00012
发表时间：
1982-01-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
BORG, GAV
通讯作者：
BORG, GAV