Macrolide-resistant Mycoplasma pneumoniae in adolescents with community-acquired pneumonia.
Macrolide-resistant Mycoplasma pneumoniae in adolescents with community-acquired pneumonia.
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DOI：
10.1186/1471-2334-12-126
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发表时间：
2012-05-31
影响因子：
3.7
通讯作者：
Atypical Pathogen Study Group
中科院分区：
文献类型：
--
作者：
Miyashita N;Kawai Y;Akaike H;Ouchi K;Hayashi T;Kurihara T;Okimoto N;Atypical Pathogen Study Group
尽管耐大环内酯类肺炎支原体在日本儿科患者中的流行率迅速上升，但在16至19岁的青少年中尚未见耐大环内酯类肺炎支原体感染的报道。本研究的目的是阐明耐大环内酯类肺炎支原体在青少年社区获得性肺炎患者中的患病率和临床特征。对经聚合酶链式反应(PCR)和培养确诊的99例肺炎支原体肺炎进行了分析。16岁以下儿童患者45例，16~19岁青少年患者26例，成人患者28例。使用23S rRNA V区的引物，将扩增产物的DNA序列与肺炎支原体参考菌株的DNA序列进行比较。45例肺炎支原体肺炎患儿中有30例(66%)、26例青少年患者中有12例(46%)、28例成人患者中有7例(25%)感染大环内酯类耐药肺炎支原体(MR)。尽管2008至2011年间儿科患者中耐药菌株的流行率相似，但青少年患者中耐药菌株的流行率有所上升。在30例儿童MR患者中，26例在2063位(A2063G)发生A-G转变，4例在2064位(A2064G)发生A-G转变。在12例青少年MR患者中，10例显示A2063G转换，2例显示A2064G转换；在7名成年MR患者中，6例显示A2063G转换，1例显示A2064G转换。耐大环内酯肺炎支原体在青少年患者和16岁以下的儿童患者中的患病率很高。为了预防肺炎支原体感染，特别是耐大环内酯类肺炎支原体在封闭人群中的暴发，包括在家庭、学校和大学生中，医生应密切关注耐大环内酯类肺炎支原体。
Although the prevalence of macrolide-resistant Mycoplasma pneumoniae isolates in Japanese pediatric patients has increased rapidly, there have been no reports concerning macrolide-resistant M. pneumoniae infection in adolescents aged 16 to 19 years old. The purpose of this study was to clarify the prevalence and clinical characteristics of macrolide-resistant M. pneumoniae in adolescent patients with community-acquired pneumonia. A total of 99 cases with M. pneumoniae pneumonia confirmed by polymerase chain reaction (PCR) and culture were analyzed. Forty-five cases were pediatric patients less than 16 years old, 26 cases were 16 to 19-year-old adolescent patients and 28 cases were adult patients. Primers for domain V of 23S rRNA were used and DNA sequences of the PCR products were compared with the sequence of an M. pneumoniae reference strain. Thirty of 45 pediatric patients (66%), 12 of 26 adolescent patients (46%) and seven of 28 adult patients (25%) with M. pneumoniae pneumonia were found to be infected with macrolide-resistant M. pneumoniae (MR patients). Although the prevalence of resistant strains was similar in pediatric patients between 2008 and 2011, an increase in the prevalence of resistant strains was observed in adolescent patients. Among 30 pediatric MR patients, 26 had an A-to-G transition at position 2063 (A2063G) and four had an A-to-G transition at position 2064 (A2064G). In 12 adolescent MR patients, 10 showed an A2063G transition and two showed an A2064G transition, and in seven adult MR patients, six showed an A2063G transition and one showed an A2064G transition. The prevalence of macrolide-resistant M. pneumoniae is high among adolescent patients as well as pediatric patients less than 16-years old. To prevent outbreaks of M. pneumoniae infection, especially macrolide-resistant M. pneumoniae, in closed populations including among families, in schools and in university students, physicians should pay close attention to macrolide-resistant M. pneumoniae.
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影响因子：
5.2
作者：
Chironna, M.;Sallustio, A.;Cardinale, F.
通讯作者：
Cardinale, F.
影响因子：
4.9
作者：
Matsuoka, M;Narita, M;Sasaki, T
通讯作者：
Sasaki, T
影响因子：
11.8
作者：
Cao, Bin;Zhao, Chun-Jiang;Wang, Chen
通讯作者：
Wang, Chen
影响因子：
2.2
作者：
Matsubara, Keita;Morozumi, Miyuki;Iwata, Satoshi
通讯作者：
Iwata, Satoshi
DOI：
10.1007/s10096-010-1107-8
发表时间：
2011-03-01
影响因子：
4.5
作者：
Miyashita, N.;Kawai, Y.;Oka, M.
通讯作者：
Oka, M.