FlyAtlas 2 in 2022: enhancements to the Drosophila melanogaster expression atlas.
FlyAtlas 2 in 2022: enhancements to the Drosophila melanogaster expression atlas.
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2022年FlyAtlas 2：对果蝇黑腹果蝇表达图谱的改进。
DOI：
10.1093/nar/gkab971
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发表时间：
2022-01-07
影响因子：
14.9
通讯作者：
Leader DP
中科院分区：
文献类型：
--
作者：
Krause SA;Overend G;Dow JAT;Leader DP
FlyAtlas 2（flyatlas2.org）是一个数据库和网络应用程序，用于研究果蝇基因在成虫和幼虫不同组织中的表达。它基于RNA-Seq数据，并结合了编码蛋白质和microRNA的基因。我们现在已经完成了数据库的人口与13个组织从男性和女性的成年人，5个性别特异性组织，和8个幼虫组织。也包括幼虫加兰细胞肾细胞。对应用程序进行了重大改进。首先，增加了一个工具，用于搜索具有与查询基因相似的组织表达模式的基因。这可能有助于建立目前未知的基因功能。其次，增加了一个专门用于幼虫中肠的设施，可以探索不同pH值的五个区域中基因表达的差异。描述了对接口的各种进一步改进。
FlyAtlas 2 (flyatlas2.org) is a database and web application for studying the expression of the genes of Drosophila melanogaster in different tissues of adults and larvae. It is based on RNA-Seq data, and incorporates both genes encoding proteins and microRNAs. We have now completed the population of the database with 13 tissues from both male and female adults, five sex-specific tissues, and eight larval tissues. Larval garland cell nephrocytes have also been included. Major enhancements have been made to the application. First, a facility has been added for a ‘Profile’ search for genes with a similar pattern of tissue expression as a query gene. This may help establish the function of genes for which this is currently unknown. Second, a facility has been added dedicated to the larval midgut, where the difference in gene expression in the five regions of different pH can be explored. A variety of further improvements to the interface are described.
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影响因子：
14.9
作者：
Gene Ontology Consortium
通讯作者：
Gene Ontology Consortium
影响因子：
14.9
作者：
Larkin A;Marygold SJ;Antonazzo G;Attrill H;Dos Santos G;Garapati PV;Goodman JL;Gramates LS;Millburn G;Strelets VB;Tabone CJ;Thurmond J;FlyBase Consortium
通讯作者：
FlyBase Consortium
影响因子：
64.5
作者：
Davie K;Janssens J;Koldere D;De Waegeneer M;Pech U;Kreft Ł;Aibar S;Makhzami S;Christiaens V;Bravo González-Blas C;Poovathingal S;Hulselmans G;Spanier KI;Moerman T;Vanspauwen B;Geurs S;Voet T;Lammertyn J;Thienpont B;Liu S;Konstantinides N;Fiers M;Verstreken P;Aerts S
通讯作者：
Aerts S
影响因子：
14.9
作者：
Leader DP;Krause SA;Pandit A;Davies SA;Dow JAT
通讯作者：
Dow JAT
影响因子：
14.8
作者：
Theocharidis, Athanasios;van Dongen, Stjin;Freeman, Tom C.
通讯作者：
Freeman, Tom C.