Continuous Theta-Burst Stimulation to the Right Dorsolateral Prefrontal Cortex May Increase Potentiated Startle in Healthy Individuals.
Continuous Theta-Burst Stimulation to the Right Dorsolateral Prefrontal Cortex May Increase Potentiated Startle in Healthy Individuals.
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DOI：
10.1016/j.bpsgos.2022.04.001
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发表时间：
2023-07
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会聚神经影像学和神经调节研究表明，右背外侧前额叶皮层（dlPFC）是参与焦虑-认知相互作用的关键区域。然而，神经影像学数据是相关的，神经调节研究往往缺乏适当的方法控制。因此，这项工作的目的是探讨右前额叶认知控制机制的表达/调节焦虑使用连续theta-突发经颅磁刺激（cTBS）和不可预测的冲击的威胁。基于先前的神经调节研究，我们假设右侧前额叶皮层有助于焦虑的表达，而cTBS应该下调这种表达。我们测量了28名健康受试者在4次（600次脉冲/次）主动或假cTBS之前和之后的斯滕贝格工作记忆范式上的增强惊吓和表现。刺激是个性化的最大工作记忆相关的活动，并优化使用电场建模的右dlPFC网站。与假cTBS相比，被认为诱导长期抑郁样突触变化的活动cTBS在休克威胁期间增加了惊吓，但对于可预测和不可预测的威胁，效果相似。作为目标（不）参与的衡量标准，我们还表明，主动而不是假cTBS降低了斯滕贝格任务的准确性。与我们最初的假设相反，右侧dlPFC的cTBS使个体更加焦虑，而不是减少焦虑。虽然是初步的，但这些结果不太可能是由于刺激的短暂效应，因为焦虑是在cTBS后24小时测量的。此外，这些结果不太可能是由于脱靶效应造成的，因为从斯滕贝格的性能数据中可以明显看出目标脱离。
Convergent neuroimaging and neuromodulation studies implicate the right dorsolateral prefrontal cortex (dlPFC) as a key region involved in anxiety-cognition interactions. However, neuroimaging data are correlational, and neuromodulation studies often lack appropriate methodological controls. Accordingly, this work was designed to explore the role of right prefrontal cognitive control mechanisms in the expression/regulation of anxiety using continuous theta-burst transcranial magnetic stimulation (cTBS) and threat of unpredictable shock. Based on prior neuromodulation studies, we hypothesized that the right dlPFC contributed to anxiety expression, and that cTBS should downregulate this expression. We measured potentiated startle and performance on the Sternberg working memory paradigm in 28 healthy participants before and after 4 sessions (600 pulses/session) of active or sham cTBS. Stimulation was individualized to the right dlPFC site of maximal working memory–related activity and optimized using electric-field modeling. Compared with sham cTBS, active cTBS, which is thought to induce long-term depression–like synaptic changes, increased startle during threat of shock, but the effect was similar for predictable and unpredictable threat. As a measure of target (dis)engagement, we also showed that active but not sham cTBS decreased accuracy on the Sternberg task. Counter to our initial hypothesis, cTBS to the right dlPFC made individuals more anxious, rather than less anxious. Although preliminary, these results are unlikely to be due to transient effects of the stimulation, because anxiety was measured 24 hours after cTBS. In addition, these results are unlikely to be due to off-target effects, because target disengagement was evident from the Sternberg performance data.
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影响因子：
4.2
作者：
Balderston NL;Flook E;Hsiung A;Liu J;Thongarong A;Stahl S;Makhoul W;Sheline Y;Ernst M;Grillon C
通讯作者：
Grillon C
影响因子：
6.8
作者：
Balderston NL;Liu J;Roberson-Nay R;Ernst M;Grillon C
通讯作者：
Grillon C
影响因子：
5.3
作者：
Bystritsky, Alexander;Kaplan, Jonas T.;Iacoboni, Marco
通讯作者：
Iacoboni, Marco
DOI：
10.1016/j.cortex.2012.05.022
发表时间：
2013-05
期刊：
Cortex; a journal devoted to the study of the nervous system and behavior
影响因子：
--
作者：
Barbey AK;Koenigs M;Grafman J
通讯作者：
Grafman J
影响因子：
7.6
作者：
Altamura, Mario;Goldberg, Terry E.;Coppola, Richard
通讯作者：
Coppola, Richard