Glucose uptake, perfusion, and cell proliferation in head and neck tumors: relation of positron emission tomography to flow cytometry.
Glucose uptake, perfusion, and cell proliferation in head and neck tumors: relation of positron emission tomography to flow cytometry.
复制标题
头颈肿瘤中的葡萄糖摄取、灌注和细胞增殖：正电子发射断层扫描与流式细胞术的关系。
作者：
U. Haberkorn;L. Strauss;C. Reisser;D. Haag;A. Dimitrakopoulou;S. Ziegler;F. Oberdorfer;V. Rudat;G. Kaick
在体内研究了18F-脱氧葡萄糖（FDG）摄取与人头颈部肿瘤增殖率的关系。42例经组织学证实的头颈部鳞状细胞癌患者和4例头颈部肿瘤转移患者在手术前接受了PET和FDG检查。在这些患者中的35例中，使用一维流式细胞术（DAPI染色）进行DNA含量和增殖率的流式细胞术分析。在17例病例中，使用15 O标记水进行灌注研究。27份标本可通过流式细胞术进行评价。FDG摄取分布的分析显示两组，显示高和低摄取模式。在两组中，FDG摄取和增殖率分别与r值0.64和0.8相关。然而，回归函数的斜率是平坦的。灌注量与增殖率之间无相关性。这表明，在组织学上相同的肿瘤群体中，这些摄取差异可能对应于分子水平上的差异，例如，葡萄糖载体数量的差异，可能由致癌转化引起。
The uptake of 18F-Deoxyglucose (FDG) was studied in vivo in relation to the proliferation rate of human head and neck tumors. Forty-two patients with histologically proven squamous-cell carcinoma of the head and neck and four patients with metastases of head and neck tumors were examined with PET and FDG prior to surgery. In 35 of these patients, a flow cytometric analysis of the DNA content and the proliferation rate was done using one-dimensional flow cytometry rate was done using one-dimensional flow cytometry (DAPI staining). In 17 cases, perfusion studies with 15O-labeled water were performed. Twenty-seven specimens were evaluable by flow cytometry. The analysis of the distribution of the FDG uptake revealed two groups, showing a high and a lower uptake pattern. In both groups the FDG uptake and the proliferation rate were correlated with an r-value of 0.64 and 0.8 respectively. However, the slope of the regression function was flat. No correlation was found between the perfusion and the proliferation rate. It is suggested that these differences in uptake in histologically identical tumor populations may correspond to differences at the molecular level, e.g., differences in the amount of the glucose carrier, perhaps caused by oncogenic transformation.
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影响因子：
56.9
作者：
FLIER, JS;MUECKLER, MM;LODISH, HF
通讯作者：
LODISH, HF
石蜡包埋切片中头颈癌 DNA 指数和 S 组分的流式细胞术分析：与恶性肿瘤分级的比较。
DOI：
10.1002/cyto.990060511
发表时间：
1985
期刊：
Cytometry
影响因子：
--
作者：
Johnson,TS;Williamson,KD;Cramer,MM;Peters,LJ
通讯作者：
Peters,LJ
DOI：
--
发表时间：
1983-09
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
M. Raichle;W. Martin;P. Herscovitch;M. Mintun;J. Markham
通讯作者：
M. Raichle;W. Martin;P. Herscovitch;M. Mintun;J. Markham
与正常和劳斯肉瘤病毒转化的鸡胚成纤维细胞中的人红细胞葡萄糖转运蛋白具有抗原相关性的蛋白质。
DOI：
10.1073/pnas.79.5.1540
发表时间：
1982
影响因子：
11.1
作者：
Salter,DW;Baldwin,SA;Lienhard,GE;Weber,MJ
通讯作者：
Weber,MJ
影响因子：
56.9
作者：
BIRNBAUM, MJ;HASPEL, HC;ROSEN, OM
通讯作者：
ROSEN, OM