Resistance to insecticides and synergism by enzyme inhibitors in Aedes albopictus from Punjab, Pakistan.
Resistance to insecticides and synergism by enzyme inhibitors in Aedes albopictus from Punjab, Pakistan.
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DOI：
10.1038/s41598-020-78226-0
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发表时间：
2020-12-03
影响因子：
4.6
通讯作者：
Khan HAA
中科院分区：
文献类型：
--
作者：
Khan HAA
杀虫剂的广泛使用产生了生态后果，如杀虫剂抗药性的出现和环境污染。白纹伊蚊是巴基斯坦旁遮普省登革热病毒的主要传播媒介。控制Ae。用杀虫剂沿着消灭白纹伊蚊是预防和控制登革热的关键，但也受到杀虫剂耐药性发展的威胁。这是野山羊草评价了旁遮普8个城市的白纹伊蚊对替美磷、溴氰菊酯和氯菊酯的抗性。对于替美磷，在拉瓦尔平迪品系的幼虫中发现了高抗性（RRLC 50> 10倍），在木尔坦、费萨拉巴德、锡亚尔科特、拉合尔和谢胡普拉品系中发现了中等抗性（RRLC 50 = 5 - 10倍），在卡苏尔和萨希瓦品系中发现了低抗性（RRLC 50 <5倍）。对于溴氰菊酯，在费萨拉巴德品系的成虫中观察到高抗性，在锡亚尔科特、谢胡普拉、拉合尔和卡苏尔品系中观察到中等抗性，在Sahiwal、木尔坦和拉瓦尔平迪品系中观察到低抗性。对于氯菊酯，所有现场菌株的成年人表现出高水平的电阻。在增效作用生物测定中，当与胡椒基丁醚或S，S，S-三丁基三硫代磷酸酯组合测试时，所有杀虫剂在田间菌株中的毒性显著增强，这表明基于代谢的抗性机制的可能性。因此，Ae.旁遮普白纹伊蚊对替美磷、溴氰菊酯和二氯苯醚菊酯表现出抗药性，这可能与抗药性的代谢机制有关。
The widespread use of insecticides has ecological consequences such as emergence of insecticide resistance and environmental pollution. Aedes albopictus is a major vector of dengue virus in the Punjab province, Pakistan. Control of Ae. albopictus with insecticides along with source eradication is critical in the prevention and control of dengue fever but is threatened by the development of insecticide resistance. Here, field strains of Ae. albopictus from eight cities of Punjab were evaluated for resistance against temephos, deltamethrin and permethrin. For temephos, high resistance (RRLC50 > tenfold) was found in larvae of the Rawalpindi strain, moderate resistance (RRLC50 = five- to tenfold) in Multan, Faisalabad, Sialkot, Lahore and Sheikhupura strains, and low resistance (RRLC50 < fivefold) in Kasur and Sahiwal strains. In the case of deltamethrin, high resistance was seen in adults of the strain from Faisalabad, moderate resistance in the strains from Sialkot, Sheikhupura, Lahore and Kasur, and low resistance in Sahiwal, Multan and Rawalpindi strains. For permethrin, adults of all the field strains exhibited high levels of resistance. In synergism bioassays, toxicity of all the insecticides in the field strains significantly enhanced when tested in combination with piperonyl butoxide or S,S,S-tributylphosphorotrithioate, suggesting the probability of metabolic-based mechanisms of resistance. In conclusion, field strains of Ae. albopictus from Punjab exhibit resistance to temephos, deltamethrin and permethrin, which might be associated with metabolic mechanisms of resistance.
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影响因子：
4.7
作者：
Hardstone, Melissa C.;Scott, Jeffrey G.
通讯作者：
Scott, Jeffrey G.
影响因子：
3.2
作者：
Kamgang B;Marcombe S;Chandre F;Nchoutpouen E;Nwane P;Etang J;Corbel V;Paupy C
通讯作者：
Paupy C
影响因子：
3.2
作者：
Demok, Samuel;Endersby-Harshman, Nancy;Karl, Stephan
通讯作者：
Karl, Stephan
影响因子：
1.9
作者：
HEMINGWAY, J;BODDINGTON, RG;DUNBAR, SJ
通讯作者：
DUNBAR, SJ
影响因子：
3.8
作者：
Marcombe, Sebastien;Fustec, Benedicte;Brey, Paul T.
通讯作者：
Brey, Paul T.