Investigations of Pro- and Anti-Apoptotic Factors Affecting African Swine Fever Virus Replication and Pathogenesis.
Investigations of Pro- and Anti-Apoptotic Factors Affecting African Swine Fever Virus Replication and Pathogenesis.
复制标题
DOI：
10.3390/v9090241
复制
发表时间：
2017-08-25
期刊：
影响因子：
--
通讯作者：
Alonso C
中科院分区：
文献类型：
--
作者：
Dixon LK;Sánchez-Cordón PJ;Galindo I;Alonso C
非洲猪瘟病毒（African swine fever virus，ASFV）是一种主要在细胞质中复制的大DNA病毒，并且是Asfarviridae家族的唯一成员。该病毒会在家猪和野猪中引起急性出血热、非洲猪瘟（ASF），导致大多数受感染动物死亡。细胞凋亡在病毒进入或脱壳期间的早期阶段被诱导。然而，ASFV编码促进子代病毒体产生的抗凋亡蛋白。这些抗凋亡蛋白包括A179 L，Bcl-2家族成员; A224 L，凋亡蛋白（IAP）家族成员的抑制剂; EP 153 R，C型凝集素;和DP 71 L。后者通过抑制应激激活的促凋亡途径促凋亡途径的激活而起作用。这些蛋白质的作用机制进行了总结。ASF疾病的特征是未感染淋巴细胞的大量凋亡，这降低了免疫反应的有效性，有助于病毒的发病机制。这种凋亡诱导的机制进行了讨论。
African swine fever virus (ASFV) is a large DNA virus that replicates predominantly in the cell cytoplasm and is the only member of the Asfarviridae family. The virus causes an acute haemorrhagic fever, African swine fever (ASF), in domestic pigs and wild boar resulting in the death of most infected animals. Apoptosis is induced at an early stage during virus entry or uncoating. However, ASFV encodes anti-apoptotic proteins which facilitate production of progeny virions. These anti-apoptotic proteins include A179L, a Bcl-2 family member; A224L, an inhibitor of apoptosis proteins (IAP) family member; EP153R a C-type lectin; and DP71L. The latter acts by inhibiting activation of the stress activated pro-apoptotic pathways pro-apoptotic pathways. The mechanisms by which these proteins act is summarised. ASF disease is characterised by massive apoptosis of uninfected lymphocytes which reduces the effectiveness of the immune response, contributing to virus pathogenesis. Mechanisms by which this apoptosis is induced are discussed.
登录
查看更多内容
影响因子：
5.4
作者：
Byers, Nathaniel M.;Vandergaast, Rianna L.;Friesen, Paul D.
通讯作者：
Friesen, Paul D.
影响因子：
0.8
作者：
Carrasco, L;deLara, FCM;Sierra, MA
通讯作者：
Sierra, MA
影响因子：
16
作者：
Harding, HP;Novoa, I;Ron, D
通讯作者：
Ron, D
DOI：
10.3390/v8110278
发表时间：
2016-10-28
期刊：
Viruses
影响因子：
--
作者：
Bajrai LH;Benamar S;Azhar EI;Robert C;Levasseur A;Raoult D;La Scola B
通讯作者：
La Scola B
影响因子：
3.7
作者：
Carrascosa, AL;Bustos, MJ;Revilla, Y
通讯作者：
Revilla, Y