Excitable Signal Transduction Networks in Directed Cell Migration.
Excitable Signal Transduction Networks in Directed Cell Migration.
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DOI：
10.1146/annurev-cellbio-100616-060739
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发表时间：
2017-10-06
影响因子：
11.3
通讯作者：
Miao Y
中科院分区：
文献类型：
--
作者：
Devreotes PN;Bhattacharya S;Edwards M;Iglesias PA;Lampert T;Miao Y
虽然定向迁移可能是为了逃避营养物质的消耗而进化的，但它已被广泛应用于发育和成年期间的一系列生理事件。这些运动的颠覆导致了疾病。虽然推进和感知的机制非常多样，但大多数细胞通过伸展充满肌动蛋白的突起（称为巨小体、伪足或板足）或通过气泡的延伸来移动。除了移动性，定向迁移还涉及极性和定向感知。参与这些过程的数百种基因产物被组织成平行和相互连接的通路网络。许多这些成分被激活或抑制协调刺激和每一个自发延长的突出。此外，这些神经网络表现出兴奋性的特征，包括“要么全有，要么全无”的反应和波传播。细胞突起是由信号转导波从一个起点向外传播并驱动细胞骨架活动引起的。传播波的范围和突起的大小可以通过降低或提高网络激活的阈值来改变，更大更宽的突起有利于滑动或振荡行为，而不是变形虫迁移。在这里，我们评估了控制定向迁移的可兴奋网络的各种模型，并概述了关键测试。我们还讨论了这一新兴观点在产生细胞迁移和整合各种直接迁移的外部线索方面的效用。
While directed migration may have evolved to escape nutrient depletion, it has been adopted for an extensive range of physiological events during development and in the adult. The subversion of these movements results in disease. Though the mechanisms of propulsion and sensing are extremely diverse, most cells move by extending actin-filled protrusions called macropinosomes, pseudopodia, or lamellipodia or by extension of blebs. In addition to motility, directed migration involves polarity and directional sensing. The hundreds of gene products involved in these processes are organized into networks of parallel and interconnected pathways. Many of these components are activated or inhibited coordinately with stimulation and on each spontaneously extended protrusion. Moreover, these networks display hallmarks of excitability, including “all-or-nothing” responsiveness and wave propagation. Cellular protrusions result from signal transduction waves which propagate outwardly from an origin and drive cytoskeletal activity. The range of the propagating waves and hence the size of the protrusions can be altered by lowering or raising the threshold for network activation, with larger and wider protrusions favoring gliding or oscillatory behavior over amoeboid migration. Here, we evaluate the variety of models of excitable networks controlling directed migration and outline critical tests. We also discuss the utility of this emerging view in producing cell migration and in integrating the various extrinsic cues that direct migration.
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影响因子：
19
作者：
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