Anterior Chamber Measurements in Healthy Children: A Cross-Sectional Study Using Optical Coherence Tomography.
Anterior Chamber Measurements in Healthy Children: A Cross-Sectional Study Using Optical Coherence Tomography.
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DOI：
10.1167/tvst.10.6.13
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发表时间：
2021-05-03
影响因子：
3
通讯作者：
Proudlock FA
中科院分区：
文献类型：
--
作者：
Edawaji BSA;Gottlob I;Proudlock FA
建立儿童前房测量方法，探讨人口学因素对前房发育的影响。手持光学相干断层扫描被用来扫描参与者的眼睛前房，没有镇静。ImageJ用于生成定量前房测量值，包括中央角膜厚度（CCT）、前房宽度、小梁网长度（TML）、Schwalbe线角开口距离（SL-AOD）和小梁虹膜表面积（SL-TISA）。使用分数多项式模型估计每个年龄组的平均前房测量值，95%预测区间。采用混合回归模型评价年龄、性别、眼、角度和屈光不正变化对前房测量的影响。包括223名健康儿童（2天至15岁）和59名成人（16至47岁）的扫描。随着年龄的增长，前房宽度、TML、Schwalbe线角张开距离和Schwalbe线小梁虹膜表面积显著增加，而CCT显著降低（均P < 0.001）。前房在前18个月内发育迅速，到5岁时成熟。女孩的前房明显小于男孩（均P < 0.001）。左右眼发育差异无统计学意义（均P > 0.05）。颞侧TML的发育明显大于鼻侧TML（P < 0.05）。CCT的发展与屈光力呈负相关。这项新颖的非侵入性研究描述了新生儿出生后前房的发育。我们建立的定量测量方法在了解眼前节疾病方面具有潜在的临床应用价值。
To establish anterior chamber measurements in children and investigate the influence of demographic factors on anterior chamber development. Handheld optical coherence tomography was used to scan the anterior chamber of participants’ eyes, without sedation. ImageJ was used to generate quantitative anterior chamber measurements, including central corneal thickness (CCT), anterior chamber width, trabecular meshwork length (TML), Schwalbe's line–angle opening distance (SL-AOD), and trabecular iris surface area (SL-TISA). The average anterior chamber measurements per age group, with 95% prediction intervals, were estimated using fractional polynomial modeling. Mixed regression models were used to evaluate the influence of age, gender, eye, angle, and refractive error variation on anterior chamber measurements. Scans from 223 healthy children (2 days to 15 years of age) and 59 adults (16 to 47 years of age) were included. The anterior chamber width, TML, Schwalbe's line–angle opening distance, and Schwalbe's line–trabecular iris surface area significantly increased, whereas CCT decreased with aging (all P < 0.001). The anterior chamber has a rapid phase of development during the first 18 months of age and reaches maturity by the age of 5 years. Girls have significantly smaller anterior chambers compared with boys (all P < 0.001). There was no difference between right and left eye development (all P > 0.05). The temporal TML development was significantly greater than the nasal TML (P < 0.05). CCT development was negatively correlated with refractive power. This novel, non-invasive study describes the postnatal development of anterior chamber in newborn children. Our established quantitative measurements have potential clinical use in understanding anterior segment diseases.
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影响因子：
13.7
作者：
Patel, Aarti;Purohit, Ravi;Lee, Helena;Sheth, Viral;Maconachie, Gail;Papageorgiou, Eleni;McLean, Rebecca J.;Gottlob, Irene;Proudlock, Frank A.
通讯作者：
Proudlock, Frank A.
影响因子：
13.7
作者：
He, Mingguang;Huang, Wenyong;Foster, Paul J.
通讯作者：
Foster, Paul J.
影响因子：
2
作者：
Friedman, David S.;Gazzard, Gus;Foster, Paul J.
通讯作者：
Foster, Paul J.
影响因子：
1.8
作者：
Pennie, FC;Wood, ICJ;Charman, WN
通讯作者：
Charman, WN
影响因子：
3.4
作者：
Pilat, Anastasia V.;Sheth, Viral;Gottlob, Irene
通讯作者：
Gottlob, Irene