Optic Nerve Head Development in Healthy Infants and Children Using Handheld Spectral-Domain Optical Coherence Tomography.
Optic Nerve Head Development in Healthy Infants and Children Using Handheld Spectral-Domain Optical Coherence Tomography.
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DOI：
10.1016/j.ophtha.2016.06.057
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发表时间：
2016-10
期刊：
影响因子：
13.7
通讯作者：
Proudlock, Frank A.
中科院分区：
文献类型：
--
作者：
Patel, Aarti;Purohit, Ravi;Lee, Helena;Sheth, Viral;Maconachie, Gail;Papageorgiou, Eleni;McLean, Rebecca J.;Gottlob, Irene;Proudlock, Frank A.
确定视神经乳头（ONH）成像的可行性，并使用手持式光谱域光学相干断层扫描（SD OCT）表征足月婴儿在无镇静情况下的ONH发展。前瞻性横断面研究。352名1天至13岁的儿童。所有参与者在单次扫描期间使用手持式SD OCT进行成像，无需镇静。计算成功扫描的百分比。使用组内相关系数（ICC）评估右眼和左眼间的重复性和差异。使用ImageJ软件分析图像。使用分数多项式模型计算ONH参数随时间的发育轨迹。椎间盘和视杯直径（以微米为单位的距离和以度为单位的视角表示）、视杯深度、布鲁赫膜开口-最小边缘宽度（BMO-MRW）、视网膜厚度和视网膜神经纤维层（RNFL; 1700 μm，与椎间盘中心成6°）。平均而言，70%的参与者成功成像。直径和视网膜厚度参数的检查者间可靠性极好（ICC，>0.89）。右眼和左眼的直径测量值相似（ICC，>0.79），但鼻BMO-MRW、RNFL和视网膜厚度变化更大。当以距离测量值表示时，出生到13岁之间的平均盘和杯直径分别增加了30%和40%，但当以相对于眼节点的视角表示时，保持不变（分别为5°-5.5°和2°）。视乳头周围颞部RNFL表现出显着的初始下降近35%的出生和约18个月的年龄。随后在距椎间盘中心1700 μm处测量时，12岁时缓慢增加，尽管在距椎间盘中心6°处测量时几乎没有变化。我们证明了在没有麻醉或镇静的情况下，对足月婴儿和儿童ONH进行手持SD OCT成像的可行性。这是第一个在体内手持式SD OCT研究，以描述在视觉成熟的关键早期的ONH参数的发展。我们的研究结果提供了一个规范的数据库，用于常规实践和进一步研究ONH的病理特征。
To determine feasibility of optic nerve head (ONH) imaging and to characterize ONH development in full-term infants without sedation using handheld spectral-domain optical coherence tomography (SD OCT). Prospective cross-sectional study. Three hundred fifty-two children aged between 1 day and 13 years. All participants were imaged using handheld SD OCT without sedation during a single scan session. The percentage of successful scans was calculated. Interexaminer reproducibility and differences between right and left eyes were assessed using intraclass correlation coefficients (ICCs). Images were analyzed using ImageJ software. The developmental trajectories over time for ONH parameters were calculated using fractional polynomial modelling. Disc and cup diameter (expressed as distance in micrometers and visual angle in degrees), cup depth, Bruch's membrane opening–minimum rim width (BMO-MRW), retinal thickness, and retinal nerve fiber layer (RNFL; 1700 μm and 6° from the disc center). On average, 70% of participants were imaged successfully. Interexaminer reliability was excellent (ICC, >0.89) for diametric and retinal thickness parameters. Right and left eyes were similar for diametric measurements (ICC, >0.79), but more variable for nasal BMO-MRW, RNFL, and retinal thickness. The mean disc and cup diameter increase by 30% and 40%, respectively, between birth and 13 years of age when expressed as a distance measure, but remained constant (at 5°–5.5° and 2°, respectively) when expressed as a visual angle with reference to the eye nodal point. The peripapillary temporal RNFL demonstrated a marked initial decrease of nearly 35% between birth and approximately 18 months of age. This was followed by a slow increase up to 12 years of age when measured at 1700 μm from the disc center, although there was little change when measured at 6° from the disc center. We demonstrated feasibility of handheld SD OCT imaging of the ONH in full-term infants and children without anaesthesia or sedation. This is the first in vivo handheld SD OCT study to describe the development of ONH parameters during the critical early years of visual maturation. Our results provide a normative database for use in routine practice and further studies of ONH pathologic features.
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影响因子：
13.7
作者：
Dobson, Velma;Clifford-Donaldson, Candice E.;Harvey, Erin M.
通讯作者：
Harvey, Erin M.
DOI：
10.3928/01913913-20100719-06
发表时间：
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作者：
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通讯作者：
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