Pregnancies complicated by gestational diabetes and fetal growth restriction: an analysis of maternal and fetal body composition using magnetic resonance imaging.
Pregnancies complicated by gestational diabetes and fetal growth restriction: an analysis of maternal and fetal body composition using magnetic resonance imaging.
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DOI：
10.1038/s41372-022-01549-5
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发表时间：
2023-01
影响因子：
2.9
通讯作者：
Calkins, Kara L.
中科院分区：
文献类型：
--
作者：
Strobel, Katie M.;Kafali, Sevgi Gokce;Shih, Shu-Fu;Artura, Alexandra M.;Masamed, Rinat;Elashoff, David;Wu, Holden H.;Calkins, Kara L.
母体的身体成分可能会影响胎儿的身体成分。本初步研究的目的是探讨母体和胎儿身体成分之间的关系。研究了三个孕妇队列：健康、妊娠期糖尿病（GDM）和胎儿生长受限（FGR）。在孕30 ~ 36周期间，使用MRI测量母体身体组成（内脏脂肪组织体积（VAT）、皮下脂肪组织体积（SAT）、胰腺和肝脏质子密度脂肪分数（PDFF））和胎儿身体组成（腹部SAT和肝脏PDFF）。与健康和FGR胎儿相比，GDM胎儿的肝脏PDFF更高（5.2[4.2，5.5]% vs. 3.2[3，3.3]% vs. 1.9[1.4，3.7]%，p=0.004）。胎儿肝脏PDFF与母体SAT（r=0.47，p=0.02）、VAT（r=0.62，p=0.002）和胰腺PDFF（r=0.54，p=0.008）相关。当控制母体SAT时，GDM使胎儿肝脏PDFF增加0.9（[0.51，1.3]%，p=0.001）。在这项研究中，母亲SAT，VAT和GDM状态与胎儿肝脏PDFF呈正相关。
Maternal body composition may influence fetal body composition. The objective of this pilot study was to investigate the relationship between maternal and fetal body composition. Three pregnant women cohorts were studied: healthy, gestational diabetes (GDM), and fetal growth restriction (FGR). Maternal body composition (visceral adipose tissue volume (VAT), subcutaneous adipose tissue volume (SAT), pancreatic and hepatic proton-density fat fraction (PDFF) and fetal body composition (abdominal SAT and hepatic PDFF) were measured using MRI between 30 to 36 weeks gestation. Compared to healthy and FGR fetuses, GDM fetuses had greater hepatic PDFF (5.2[4.2,5.5]% vs. 3.2[3,3.3]% vs. 1.9[1.4,3.7]%, p=0.004). Fetal hepatic PDFF was associated with maternal SAT (r=0.47, p=0.02), VAT (r=0.62, p=0.002), and pancreatic PDFF (r=0.54, p=0.008). When controlling for maternal SAT, GDM increased fetal hepatic PDFF by 0.9 ([0.51,1.3]%, p=0.001). In this study, maternal SAT, VAT, and GDM status were positively associated with fetal hepatic PDFF.
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影响因子：
7.1
作者：
Anblagan, D.;Deshpande, R.;Mansell, P.
通讯作者：
Mansell, P.
影响因子：
4.4
作者：
Armstrong, Tess;Liu, Dapeng;Wu, Holden H.
通讯作者：
Wu, Holden H.
DOI：
10.1002/hep.29797
发表时间：
2018-08
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Caussy C;Reeder SB;Sirlin CB;Loomba R
通讯作者：
Loomba R
影响因子：
--
作者：
Bader J;Carson M;Enos R;Velazquez K;Sougiannis A;Singh U;Becker W;Nagarkatti M;Fan D;Murphy A
通讯作者：
Murphy A
DOI：
10.1016/s0002-9378(03)00828-7
发表时间：
2003-12-01
影响因子：
9.8
作者：
Catalano, PM;Thomas, A;Amini, SB
通讯作者：
Amini, SB