Quantification of Myocardial Creatine and Triglyceride Content in the Human Heart: Precision and Accuracy of in vivo Proton Magnetic Resonance Spectroscopy.
Quantification of Myocardial Creatine and Triglyceride Content in the Human Heart: Precision and Accuracy of in vivo Proton Magnetic Resonance Spectroscopy.
复制标题
DOI：
10.1002/jmri.27531
复制
发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Nederveen AJ
中科院分区：
文献类型：
--
作者：
Bakermans AJ;Boekholdt SM;de Vries DK;Reckman YJ;Farag ES;de Heer P;Uthman L;Denis SW;Zuurbier CJ;Houtkooper RH;Koolbergen DR;Kluin J;Planken RN;Lamb HJ;Webb AG;Strijkers GJ;Beard DA;Jeneson JAL;Nederveen AJ
人类心脏的质子磁共振波谱（1H-MRS）被认为是研究心肌代谢物含量的定量方法，但缺乏针对侵入性技术的体内测量的彻底验证。确定局部1H-MRS定量心肌总肌酸和甘油三酯含量的测量精密度和准确度。重测重复性和测量确认研究。16名志愿者和22名患者计划接受心内直视主动脉瓣置换术或间隔肌切除术。在3 T下，Proximal ECG触发呼吸门控自由呼吸单体素点分辨光谱（PRESS）序列。通过拟合1H-MR光谱，相对于总含水量定量心肌总肌酸和甘油三酯含量。通过测量重复性评估精密度。通过验证体内1H-MRS测量值与相同受试者心肌组织中的生化测定值，评估准确性。使用Bland-Altman分析评估了会话内和会话间的可重复性。用回归分析检验1H-MRS测量和生化测定之间的一致性。心肌总肌酸含量的间期重复性系数为41.8%，平均值为总水信号的0.083% ± 0.020%;心肌甘油三酯含量的间期重复性系数为36.7%，平均值为总水信号的0.35% ± 0.13%。离体组织样本中心肌总肌酸浓度与1H-MRS测量的体内心肌总肌酸含量相关：n = 22，r = 0.44; P < 0.05。同样，离体心肌甘油三酯浓度与体内心肌甘油三酯含量相关：n = 20，r = 0.50; P < 0.05。我们通过估计测量精密度和准确度，验证了在3 T下使用人体心脏的局部1H-MRS定量评估体内心肌组织代谢物含量。2 2
Proton magnetic resonance spectroscopy (1H‐MRS) of the human heart is deemed to be a quantitative method to investigate myocardial metabolite content, but thorough validations of in vivo measurements against invasive techniques are lacking. To determine measurement precision and accuracy for quantifications of myocardial total creatine and triglyceride content with localized 1H‐MRS. Test–retest repeatability and measurement validation study. Sixteen volunteers and 22 patients scheduled for open‐heart aortic valve replacement or septal myectomy. Prospectively ECG‐triggered respiratory‐gated free‐breathing single‐voxel point‐resolved spectroscopy (PRESS) sequence at 3 T. Myocardial total creatine and triglyceride content were quantified relative to the total water content by fitting the 1H‐MR spectra. Precision was assessed with measurement repeatability. Accuracy was assessed by validating in vivo 1H‐MRS measurements against biochemical assays in myocardial tissue from the same subjects. Intrasession and intersession repeatability was assessed using Bland–Altman analyses. Agreement between 1H‐MRS measurements and biochemical assay was tested with regression analyses. The intersession repeatability coefficient for myocardial total creatine content was 41.8% with a mean value of 0.083% ± 0.020% of the total water signal, and 36.7% for myocardial triglyceride content with a mean value of 0.35% ± 0.13% of the total water signal. Ex vivo myocardial total creatine concentrations in tissue samples correlated with the in vivo myocardial total creatine content measured with 1H‐MRS: n = 22, r = 0.44; P < 0.05. Likewise, ex vivo myocardial triglyceride concentrations correlated with the in vivo myocardial triglyceride content: n = 20, r = 0.50; P < 0.05. We validated the use of localized 1H‐MRS of the human heart at 3 T for quantitative assessments of in vivo myocardial tissue metabolite content by estimating the measurement precision and accuracy. 2 2
登录
查看更多内容
DOI：
10.1007/s10334-003-0029-1
发表时间：
2004-03-01
影响因子：
2.3
作者：
Krssak, M;Mlynárik, V;Roden, M
通讯作者：
Roden, M
影响因子：
3.3
作者：
O'Connor, Robert D.;Xu, Jian;Ewald, Gregory A.;Ackerman, Joseph J. H.;Peterson, Linda R.;Gropler, Robert J.;Bashir, Adil
通讯作者：
Bashir, Adil
DOI：
10.1111/j.1559-4572.2009.00061.x
发表时间：
2009-09
期刊：
Journal of clinical hypertension (Greenwich, Conn.)
影响因子：
--
作者：
O'Connor RD;Bashir A;Cade WT;Yarasheski KE;Gropler RJ
通讯作者：
Gropler RJ
影响因子：
3.3
作者：
DENHOLLANDER, JA;EVANOCHKO, WT;POHOST, GM
通讯作者：
POHOST, GM
DOI：
10.1016/s0022-2828(84)80015-2
发表时间：
1984-01-01
影响因子：
5
作者：
FIOLET, JWT;BAARTSCHEER, A;TERWELLE, HF
通讯作者：
TERWELLE, HF