Effect of resistance training on biomarkers of vascular function and oxidative stress in young African-American and Caucasian men.
Effect of resistance training on biomarkers of vascular function and oxidative stress in young African-American and Caucasian men.
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DOI：
10.1038/jhh.2012.48
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发表时间：
2013-06
影响因子：
2.7
通讯作者：
中科院分区：
文献类型：
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作者：
非裔美国人（AA）的高血压发病较早，与高加索人（Cau）同龄人相比，其血管特征不同。研究表明，在高血压人群中，血管炎症的生物介质在这些人群中是不同的。抗阻训练（RT）是一种重要的运动方式，可以改善年轻AA男性的血管轮廓。我们在BMI匹配的AA和Cau男性中研究了RT对血管功能和氧化应激生物标志物的作用。六周的RT引起年轻AA男性（n= 14 AA; n= 18 Cau; 18-35 yo）的循环MMP-9和8-异前列烷（8-IsoP）的显著变化。MMP-9在AA中较低且减少（治疗前：p=0.02;治疗后：p<0.001），并且检测到MMP-9（F1，30=4.81; p=0.036）和8-IsoP（F1，24=7.09; p=0.014）的时间x组相互作用。8-AA中IsoP降低（p=0.026），但Cau中无变化（p=0.309）。值得注意的是，强度（1-RM）的增加与MMP-9的降低相关（r=-0.398; p=0.022）。此外，这些适应性变化与心肺适应性的任何改善无关。我们证明，RT有效地降低基质重塑蛋白和氧化应激在年轻的AA男性。增加力量可能有利于改善年轻AA男性的血管健康和抵消高血压的新CV风险因素。
African Americans (AA) have an earlier onset of hypertension and a different vascular profile than their Caucasian (Cau) peers. Research suggests that biological mediators of vascular inflammation are different among these groups in hypertensive populations. Resistance training (RT) is an important exercise modality which improves the vascular profile of young AA men. We examined the role of RT on biomarkers of vascular function and oxidative stress in BMI-matched AA and Cau men. Six weeks of RT elicited significant changes in circulating MMP-9 and 8-Isoprostane (8-IsoP) in young AA men (n= 14 AA; n= 18 Cau; 18–35 yo). MMP-9 was lower and decreased in AA (pre: p=0.02; post: p<0.001) and a time x group interaction forMMP-9 (F1,30=4.81; p=0.036)and 8-IsoP(F1,24=7.09; p=0.014) was detected. 8-IsoP decreased in AA (p=0.026) but did not change in Cau (p=0.309). Notably, the increase in strength (1-RM) was correlated with the decrease in MMP-9 (r= −0.398; p=0.022). Further, these adaptations were independent of any improvement in cardiorespiratory fitness. We demonstrate that RT effectively reduces matrix remodeling proteins and oxidative stress in young AA men. Increasing strength may be beneficial for improving vascular health and offsetting novel CV risk factors of hypertension in young AA men.
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影响因子：
2.8
作者：
Ferdinand, Keith C.
通讯作者：
Ferdinand, Keith C.
影响因子：
8.3
作者：
Maiorana, Andrew J.;Naylor, Louise H.;Green, Daniel J.
通讯作者：
Green, Daniel J.
DOI：
10.1249/mss.0b013e3181d8d834
发表时间：
2010-09-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Fahs, Christopher A.;Heffernan, Kevin S.;Fernhall, Bo
通讯作者：
Fernhall, Bo
影响因子：
2.4
作者：
Calle MC;Fernandez ML
通讯作者：
Fernandez ML
DOI：
10.1152/ajpregu.90936.2008
发表时间：
2009-04-01
影响因子：
2.8
作者：
Heffernan, Kevin S.;Jae, Sae Young;Fernhall, Bo
通讯作者：
Fernhall, Bo