Alleviation of mycotoxin biodegradation agent on zearalenone and deoxynivalenol toxicosis in immature gilts.
Alleviation of mycotoxin biodegradation agent on zearalenone and deoxynivalenol toxicosis in immature gilts.
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霉菌毒素生物降解剂对未成熟后备母猪玉米赤霉烯酮和脱氧雪腐镰刀菌烯醇中毒的缓解
DOI：
10.1186/s40104-018-0255-z
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发表时间：
2018
影响因子：
7
通讯作者：
Ma Q
中科院分区：
文献类型：
--
作者：
Shi D;Zhou J;Zhao L;Rong X;Fan Y;Hamid H;Li W;Ji C;Ma Q
背景本研究旨在评价由枯草芽孢杆菌（Bacillus subtilisANSB 01 G）和Devosiasp. ANSB 714）对缓解未成年母猪玉米赤霉烯酮（ZEA）和脱氧雪腐镰刀菌烯醇（DON）中毒的作用（61.42 ± 1.18）kg，随机分为4组：（阳性对照）; MO（阴性对照，ZEA 596.86 μg/kg饲料和DON 796 μg/kg饲料）; COA（CO + 2 g MBA/kg饲料）; MOA（MO + 2 g MBA/kg饲料）。每个处理组包含10个重复，每个重复1头后备母猪。母猪被安置在一个环境控制的房间，部分板条flat.ResultsDuring整个实验期间的28 d，平均日增重（ADG）和平均日采食量（ADFI）的母猪在MO组与CO组相比，显着降低。小母猪的外阴大小MO组显著高于CO组。MO组血浆伊加、IgG、IL-8、IL-10和PRL水平较CO组显著升高。饲料中ZEA和DON可上调卵巢和子宫中凋亡的caspase-3，沿着下调卵巢中抗凋亡蛋白Bcl-2。在ZEA和DON混合污染的日粮中添加MBA可显著提高母猪的日增重，降低外阴尺寸，降低血浆中IgG、IL-8和PRL水平，并调节卵巢和子宫的细胞凋亡（596.86 μg/kg + 796 μg/kg）对母猪的生长性能、血浆免疫功能和繁殖状况有不利影响。MBA可以降低这两种毒素对后备母猪的不良影响，是一种很有前途的低水平缓解ZEA和DON中毒的饲料添加剂。
BackgroundThe current study was carried out to evaluate the effects of mycotoxin biodegradation agent (MBA, composed ofBacillus subtilisANSB01G andDevosiasp. ANSB714) on relieving zearalenone (ZEA) and deoxynivalenol (DON) toxicosis in immature gilts.MethodsA total of forty pre-pubertal female gilts (61.42 ± 1.18 kg) were randomly allocated to four diet treatments: CO (positive control); MO (negative control, ZEA 596.86 μg/kg feed and DON 796 μg/kg feed); COA (CO + 2 g MBA/kg feed); MOA (MO + 2 g MBA/kg feed). Each treatment contained 10 replicates with 1 gilt per replicate. Gilts were housed in an environmentally controlled room with the partially slatted floor.ResultsDuring the entire experimental period of 28 d, average daily gain (ADG) and average daily feed intake (ADFI) of gilts in MO group was significantly reduced compared with those in CO group. The vulva size of gilts was significantly higher in MO group than CO group. In addition, significant increases in the plasma levels of IgA, IgG, IL-8, IL-10 and PRL were determined in MO group compared with that in CO group. ZEA and DON in the diet up-regulated apoptotic caspase-3 in ovaries and uteri, along with down-regulated the anti-apoptotic protein Bcl-2 in ovaries. The supplementation of MBA into diets co-contaminated with ZEA and DON significantly increased ADG, decreased the vulva sizes, reduced the levels of IgG, IL-8 and PRL in plasma, and regulated apoptosis in ovaries and uteri of gilts.ConclusionsThe present results indicated that feeding diet contaminated with ZEA and DON simultaneously (596.86 μg/kg + 796 μg/kg) had detrimental effects on growth performance, plasma immune function and reproductive status of gilts. And MBA could reduce the negative impacts of these two toxins, believed as a promising feed additive for mitigating toxicosis of ZEA and DON at low levels in gilts.
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影响因子：
3.8
作者：
Amuzie, Chidozie J.;Pestka, James J.
通讯作者：
Pestka, James J.
影响因子：
8.8
作者：
Belhassen, H.;Jimenez-Diaz, I.;Hedili, A.
通讯作者：
Hedili, A.
影响因子：
4.3
作者：
Belli, Patrick;Bellaton, Claire;Le Jan, Christian
通讯作者：
Le Jan, Christian
DOI：
10.1016/j.ijfoodmicro.2013.06.002
发表时间：
2013-08-16
影响因子：
5.4
作者：
Cserhati, M.;Kriszt, B.;Kukolya, J.
通讯作者：
Kukolya, J.
Nocardioides sp。菌株WSN05-2，从小麦场分离出来，降解脱氧烯醇，产生新型的中间3-EPI-脱氧烯醇。
影响因子：
5
作者：
Ikunaga, Yoko;Sato, Ikuo;Grond, Stephanie;Numaziri, Nobutaka;Yoshida, Shigenobu;Yamaya, Hiroko;Hiradate, Syuntaro;Hasegawa, Morifumi;Toshima, Hiroaki;Koitabashi, Motoo;Ito, Michihiro;Karlovsky, Petr;Tsushima, Seiya
通讯作者：
Tsushima, Seiya