Human cytomegalovirus infection enhances NF-κB/p65 signaling in inflammatory breast cancer patients.
Human cytomegalovirus infection enhances NF-κB/p65 signaling in inflammatory breast cancer patients.
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DOI：
10.1371/journal.pone.0055755
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Mohamed MM
中科院分区：
文献类型：
--
作者：
El-Shinawi M;Mohamed HT;El-Ghonaimy EA;Tantawy M;Younis A;Schneider RJ;Mohamed MM
人类巨细胞病毒（HCMV）是一种地方性疱疹病毒，在癌症患者中重新出现，增强了致癌潜力。最近的研究表明，HCMV感染与某些类型的癌症发病率（如胶质母细胞瘤）有关。虽然HCMV已在乳腺癌组织中检测到，但其在特定形式乳腺癌病因学中的作用（如果有的话）尚未得到调查。在本研究中，我们研究了HCMV感染在炎症性乳腺癌（IBC）中的存在，IBC是一种以特定分子特征为特征的快速进展的乳腺癌。我们筛选了49例非IBC浸润性导管癌（IDC）和28例IBC患者外周血抗cmv IgG抗体。此外，我们在非IBC和IBC患者的术后肿瘤和非癌性乳腺组织中筛查了HCMV-DNA。我们还测试了HCMV感染是否可以调节转录因子NF-κB/p65的表达和激活，这是IBC的标志。我们的研究结果显示，与非IBC患者相比，IBC患者的HCMV IgG抗体滴度具有统计学显著性升高。HCMV-DNA在IBC和IDC癌组织中明显高于癌旁非癌组织，且IBC癌组织中HCMV-DNA的感染率明显高于IDC。此外，HCMV序列分析在IBC患者组织中检测到不同的HCMV菌株，而在IDC标本中没有检测到。此外，与非IBC患者相比，hcmv感染的IBC癌组织中NF-κB/p65信号表达增强。目前的结果表明HCMV感染与IBC之间存在相关性。HCMV感染IBC的病因学和因果关系现在需要严格检查。
Human Cytomegalovirus (HCMV) is an endemic herpes virus that re-emerges in cancer patients enhancing oncogenic potential. Recent studies have shown that HCMV infection is associated with certain types of cancer morbidity such as glioblastoma. Although HCMV has been detected in breast cancer tissues, its role, if any, in the etiology of specific forms of breast cancer has not been investigated. In the present study we investigated the presence of HCMV infection in inflammatory breast cancer (IBC), a rapidly progressing form of breast cancer characterized by specific molecular signature. We screened for anti-CMV IgG antibodies in peripheral blood of 49 non-IBC invasive ductal carcinoma (IDC) and 28 IBC patients. In addition, we screened for HCMV-DNA in postsurgical cancer and non-cancer breast tissues of non-IBC and IBC patients. We also tested whether HCMV infection can modulate the expression and activation of transcriptional factor NF-κB/p65, a hallmark of IBC. Our results reveal that IBC patients are characterized by a statistically significant increase in HCMV IgG antibody titers compared to non-IBC patients. HCMV-DNA was significantly detected in cancer tissues than in the adjacent non-carcinoma tissues of IBC and IDC, and IBC cancer tissues were significantly more infected with HCMV-DNA compared to IDC. Further, HCMV sequence analysis detected different HCMV strains in IBC patients tissues, but not in the IDC specimens. Moreover, HCMV-infected IBC cancer tissues were found to be enhanced in NF-κB/p65 signaling compared to non-IBC patients. The present results demonstrated a correlation between HCMV infection and IBC. Etiology and causality of HCMV infection with IBC now needs to be rigorously examined.
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NF-KAPPA B基因在炎症性乳腺癌中具有重要作用。
影响因子：
3.8
作者：
Lerebours F;Vacher S;Andrieu C;Espie M;Marty M;Lidereau R;Bieche I
通讯作者：
Bieche I
影响因子：
15.9
作者：
Baryawno, Ninib;Rahbar, Afsar;Soderberg-Naucler, Cecilia
通讯作者：
Soderberg-Naucler, Cecilia
影响因子：
5.4
作者：
Chan, Gary;Bivins-Smith, Elizabeth R.;Yurochko, Andrew D.
通讯作者：
Yurochko, Andrew D.
DOI：
10.1186/2042-4280-2-10
发表时间：
2011-10-26
期刊：
Herpesviridae
影响因子：
--
作者：
Cobbs CS
通讯作者：
Cobbs CS
影响因子：
2.8
作者：
Fawzy, Shereen;Sallam, Maha;Awad, Nahla Mohammad
通讯作者：
Awad, Nahla Mohammad