Oral Health, Diabetes, and Inflammation: Effects of Oral Hygiene Behaviour.
Oral Health, Diabetes, and Inflammation: Effects of Oral Hygiene Behaviour.
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DOI：
10.1016/j.identj.2021.10.001
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发表时间：
2022-08
影响因子：
3.3
通讯作者：
Schwartz, Mark D.
中科院分区：
文献类型：
--
作者：
Luo, Huabin;Wu, Bei;Kamer, Angela R.;Adhikari, Samrachana;Sloan, Frank;Plassman, Brenda L.;Tan, Chenxin;Qi, Xiang;Schwartz, Mark D.
本研究的目的是评估炎症与口腔健康和糖尿病之间的关系，以及口腔卫生习惯在这种关系中的中介作用。数据来自2009-2010年全国健康和营养调查。分析样本包括2，191名50岁及以上的受访者。口腔健康不良在临床上被定义为严重的牙齿脱落（STL）和牙周病（PD）。糖尿病（DM）由血糖水平确定。结果变量为血清C反应蛋白（CRP）水平，分为≥1 mg/dL（CRP升高）vs <1 mg/dL（CRP未升高）。两个路径模型，一个使用STL和DM作为自变量，另一个使用PD和DM作为自变量，进行了估计，以评估口腔健康不良和DM对CRP升高的直接影响和牙线的中介作用。在路径模型1中，具有STL和DM两者的个体（校正比值比[AOR]，1.92; 95%置信区间[CI]，1.30-2.82）或单独患有STL（AOR，2.30; 95% CI，1.68-3.15）比非STL或DM患者更可能有CRP升高;使用牙线（AOR，0.92，95%CI，0.88-0.96）与CRP升高风险降低相关。在路径模型2中，未发现PD和DM与CRP升高之间存在显著相关性;使用牙线（AOR，0.91; 95%CI：，0.86-0.94）与CRP升高风险较低相关。这项研究的结果强调了改善口腔健康和口腔卫生习惯以减轻炎症的重要性。需要进一步的研究来评估减少炎症的长期影响。
The aim of this research was to assess the association between inflammation and oral health and diabetes, as well as the mediating role of oral hygiene practice in this association. Data were from the 2009–2010 National Health and Nutrition Examination Survey. The analytical sample consisted of 2,191 respondents aged 50 and older. Poor oral health was clinically defined by significant tooth loss (STL) and periodontal disease (PD). Diabetes mellitus (DM) was determined by glycemic levels. The outcome variable was serum C-reactive protein (CRP) level, dichotomised as ≥1 mg/dL (elevated CRP) vs <1 mg/dL (not elevated CRP). Two path models, one using STL and DM as the independent variable, the other using PD and DM as the independent variable, were estimated to assess the direct effects of having poor oral health and DM on elevated CRP and the mediating effects of dental flossing. In path model 1, individuals having both STL and DM (adjusted odds ratio [AOR], 1.92; 95% confidence interval [CI], 1.30–2.82) or having STL alone (AOR, 2.30; 95% CI, 1.68–3.15) were more likely to have elevated CRP than those with neither STL nor DM; dental flossing (AOR, 0.92, 95% CI, 0.88–0.96) was associated with lower risk of elevated CRP. In path model 2, no significant association was found between having both PD and DM and elevated CRP; dental flossing (AOR, 0.91; 95% CI:, 0.86–0.94) was associated with lower risk of elevated CRP. Findings from this study highlight the importance of improving oral health and oral hygiene practice to mitigate inflammation. Further research is needed to assess the longer-term effects of reducing inflammation.
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影响因子：
2
作者：
Wu B;Anderson RA;Pei Y;Xu H;Nye K;Poole P;Bunn M;Lynn Downey C;Plassman BL
通讯作者：
Plassman BL
DOI：
10.1093/gerona/glaa096
发表时间：
2021-02-01
影响因子：
5.1
作者：
Kotronia, Eftychia;Wannamethee, S. Goya;Ramsay, Sheena E.
通讯作者：
Ramsay, Sheena E.
影响因子：
--
作者：
Slade, GD;Ghezzi, EM;Offenbacher, S
通讯作者：
Offenbacher, S
影响因子：
5.3
作者：
You, Zhiying;Cushman, Mary;Jenny, Nancy S.;Howard, George
通讯作者：
Howard, George
影响因子：
3.4
作者：
Meisel P;Pink C;Pitchika V;Nauck M;Völzke H;Kocher T
通讯作者：
Kocher T