Obesity and Fibrosis: Setting the Stage for Breast Cancer.
Obesity and Fibrosis: Setting the Stage for Breast Cancer.
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肥胖是绝经后妇女患乳腺癌的重要危险因素。无论绝经状态如何，肥胖妇女的转移发生率升高，对治疗的反应降低。了解肥胖如何促进乳腺癌的发展和进展可以改善肥胖妇女的干预措施。乳房组织含有脂肪。为了应对肥胖，乳房组织脂肪含有更多的胶原蛋白，包围着脂肪细胞和上皮细胞。脂肪内的支持细胞增加胶原蛋白的产生，从而提高组织的硬度。称为巨噬细胞的炎性细胞与脂肪内的其他支持细胞相互作用，以增加周围乳房组织中的胶原蛋白。虽然减肥被推荐用于减少肥胖，但对改善炎症和胶原蛋白量的长期影响尚不清楚。乳腺组织内胶原蛋白和炎症的增加可能会增加肿瘤发展的风险，并促进与预后恶化相关的特征。肥胖是一个日益严重的健康问题，与乳腺癌预后恶化有关。肿瘤结缔组织增生，其特征在于癌相关成纤维细胞的数量增加和基质内纤维状胶原的沉积，可能有助于肥胖症乳腺癌的侵袭性临床行为。乳腺的主要组成部分是脂肪组织，由于肥胖引起的脂肪组织纤维化变化可能有助于乳腺癌的发展和所产生肿瘤的生物学。脂肪组织纤维化是多种来源的肥胖的结果。脂肪细胞和脂肪源性基质细胞分泌由胶原蛋白家族成员和基质细胞蛋白组成的细胞外基质，这些蛋白会因肥胖而改变。脂肪组织也成为慢性巨噬细胞驱动的炎症的部位。巨噬细胞在肥胖脂肪组织中以不同的群体存在，并通过分泌生长因子和基质细胞蛋白以及与其他基质细胞的相互作用介导纤维化的发展。虽然减肥被推荐用于解决肥胖问题，但减肥对脂肪组织纤维化和乳腺组织炎症的长期影响尚不清楚。乳腺组织内纤维化的增加可能会增加肿瘤发展的风险，并促进与肿瘤侵袭性相关的特征。
Obesity is a significant risk factor for breast cancer in postmenopausal women. Regardless of menopausal status, women with obesity have an elevated incidence of metastasis and a decreased response to treatment. Understanding how obesity promotes the development and progression of breast cancer could improve interventions for women with obesity. Breast tissue contains fat. In response to obesity, breast tissue fat contains more collagen that surrounds the fat cells and epithelial cells. Supportive cells within the fat increase collagen production, which elevates the stiffness of the tissue. Inflammatory cells called macrophages interact with other supportive cells within the fat to increase collagen in the surrounding breast tissue. While weight loss is recommended to reduce obesity, the long-term effects on improving inflammation and the amount of collagen are less clear. Increased collagen and inflammation within breast tissue may enhance the risk for tumor development and promote characteristics associated with a worsened prognosis. Obesity is a rising health concern and is linked to a worsened breast cancer prognosis. Tumor desmoplasia, which is characterized by elevated numbers of cancer-associated fibroblasts and the deposition of fibrillar collagens within the stroma, may contribute to the aggressive clinical behavior of breast cancer in obesity. A major component of the breast is adipose tissue, and fibrotic changes in adipose tissue due to obesity may contribute to breast cancer development and the biology of the resulting tumors. Adipose tissue fibrosis is a consequence of obesity that has multiple sources. Adipocytes and adipose-derived stromal cells secrete extracellular matrix composed of collagen family members and matricellular proteins that are altered by obesity. Adipose tissue also becomes a site of chronic, macrophage-driven inflammation. Macrophages exist as a diverse population within obese adipose tissue and mediate the development of fibrosis through the secretion of growth factors and matricellular proteins and interactions with other stromal cells. While weight loss is recommended to resolve obesity, the long-term effects of weight loss on adipose tissue fibrosis and inflammation within breast tissue are less clear. Increased fibrosis within breast tissue may increase the risk for tumor development as well as promote characteristics associated with tumor aggressiveness.
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DOI：
10.1016/j.biocel.2009.12.011
发表时间：
2010-05
影响因子：
4
作者：
Choi, Young H.;Burdick, Marie D.;Strieter, Robert M.
通讯作者：
Strieter, Robert M.
DOI：
10.1186/1755-1536-4-2
发表时间：
2011-01-10
期刊：
Fibrogenesis & tissue repair
影响因子：
--
作者：
Keeley EC;Mehrad B;Strieter RM
通讯作者：
Strieter RM
影响因子：
7.7
作者：
Alessi, MC;Bastelica, D;Juhan-Vague, I
通讯作者：
Juhan-Vague, I
影响因子：
5.2
作者：
Belhabib I;Zaghdoudi S;Lac C;Bousquet C;Jean C
通讯作者：
Jean C
影响因子：
5.8
作者：
Aron-Wisnewsky, Judith;Tordjman, Joan;Clement, Karine
通讯作者：
Clement, Karine