Assessment of Anti-SARS-CoV-2 Antibodies Post-Coronavac Vaccination in the Amazon Region of Brazil.
Assessment of Anti-SARS-CoV-2 Antibodies Post-Coronavac Vaccination in the Amazon Region of Brazil.
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DOI：
10.3390/vaccines9101169
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发表时间：
2021-10-12
期刊：
影响因子：
7.8
通讯作者：
Vallinoto ACR
中科院分区：
文献类型：
--
作者：
Bichara CDA;Queiroz MAF;da Silva Graça Amoras E;Vaz GL;Vallinoto IMVC;Bichara CNC;Amaral IPCD;Ishak R;Vallinoto ACR
本研究评价了接种免疫剂Coronavac的个体中抗SARS-CoV-2（S1和S2）总抗体和抗SARS-CoV-2（受体结合域-RBD-S1）中和抗体的血清阳性频率。这是一项横断面研究，涉及358人，分为两组。第1组由205名志愿者组成，他们接受了抗SARS-CoV-2总抗体检测;第2组由153名个体组成，他们接受了抗SARS-CoV-2中和抗体检测。两组的血清阳性率均大于70%，但分别有17.6%和20.9%的个体显示无中和或总抗体反应性。抗SARS-CoV-2总抗体的频率在性别之间显示出显著不同的分布，但不随年龄而变化。SARS冠状病毒2型中和抗体阳性率为93.3%在21 ~ 40岁年龄组中（95%CI 68.1-99.8），但随年龄增长而显著降低，为76.2%，（95% CI 52.8-91.8），61 - 80岁为72.5%（95% CI 62.8-80.9），>80岁为46.7%（95% CI 21.3-73.4）。我们的研究结果显示，在接受两种剂量冠状病毒疫苗的个体中，抗SARS-CoV-2总抗体和抗SARS-CoV-2中和抗体的患病率很高，这表明60岁以上的人体液免疫应答的有效性较低，这可能与免疫系统的衰老有关。
The present study evaluated the frequency of seropositivity for anti-SARS-CoV-2 (S1 and S2) total antibodies and anti-SARS-CoV-2 (receptor binding domain-RBD-S1) neutralizing antibodies in individuals vaccinated with the immunizing agent Coronavac. This was a cross-sectional study involving 358 individuals divided into two groups. Group 1 consisted of 205 volunteers who were tested for anti-SARS-CoV-2 total antibodies; group 2 consisted of 153 individuals tested for the presence of anti-SARS-CoV-2 neutralizing antibodies. Seropositivity was greater than 70% in both groups, although 17.6% and 20.9% of individuals showed no neutralizing or total antibody reactivity, respectively. The frequency of anti-SARS-CoV-2 total antibodies displayed a significantly different distribution between the sexes but not according to age. The frequency of anti-SARS-CoV-2 neutralizing antibodies was 93.3% (95% CI 68.1–99.8) in the age group from 21 to 40 years but significantly decreased with advancing age, and was 76.2% (95% CI 52.8–91.8) for 41 to 60 years, 72.5% (95% CI 62.8–80.9) for 61 to 80 years, and 46.7% (95% CI 21.3–73.4) for >80 years. Our results reveal a high prevalence of anti-SARS-CoV-2 total antibodies and anti-SARS-CoV-2 neutralizing antibodies in individuals who received both doses of the Coronavac vaccine, suggesting a lower effectiveness of the humoral immune response among those older than 60 years of age, which might be associated with senescence of the immune system.
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影响因子：
11.8
作者：
Gallais F;Velay A;Nazon C;Wendling MJ;Partisani M;Sibilia J;Candon S;Fafi-Kremer S
通讯作者：
Fafi-Kremer S
影响因子：
7.8
作者：
Park JH;Lee HK
通讯作者：
Lee HK
DOI：
10.1177/17455065211022262
发表时间：
2021-01
期刊：
Women's health (London, England)
影响因子：
--
作者：
Ciarambino T;Para O;Giordano M
通讯作者：
Giordano M
影响因子：
6.6
作者：
Cheng C;Wang HY;Chan L
通讯作者：
Chan L
影响因子：
4.8
作者：
Fedele, Flora;Aria, Massimo;De Marco, Giulio
通讯作者：
De Marco, Giulio